1n27

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{{STRUCTURE_1n27| PDB=1n27 | SCENE= }}
{{STRUCTURE_1n27| PDB=1n27 | SCENE= }}
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'''Solution structure of the PWWP domain of mouse Hepatoma-derived growth factor, related protein 3'''
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===Solution structure of the PWWP domain of mouse Hepatoma-derived growth factor, related protein 3===
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==Overview==
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Among the many PWWP-containing proteins, the largest group of homologous proteins is related to hepatoma-derived growth factor (HDGF). Within a well-conserved region at the extreme N-terminus, HDGF and five HDGF-related proteins (HRPs) always have a PWWP domain, which is a module found in many chromatin-associated proteins. In this study, we determined the solution structure of the PWWP domain of HDGF-related protein-3 (HRP-3) by NMR spectroscopy. The structure consists of a five-stranded beta-barrel with a PWWP-specific long loop connecting beta2 and beta3 (PR-loop), followed by a helical region including two alpha-helices. Its structure was found to have a characteristic solvent-exposed hydrophobic cavity, which is composed of an abundance of aromatic residues in the beta1/beta2 loop (beta-beta arch) and the beta3/beta4 loop. A similar ligand binding cavity occurs at the corresponding position in the Tudor, chromo, and MBT domains, which have structural and probable evolutionary relationships with PWWP domains. These findings suggest that the PWWP domains of the HDGF family bind to some component of chromatin via the cavity.
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{{ABSTRACT_PUBMED_15689505}}
==About this Structure==
==About this Structure==
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1N27 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1N27 OCA].
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1N27 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1N27 OCA].
==Reference==
==Reference==
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[[Category: Rsgi]]
[[Category: Rsgi]]
[[Category: Structural genomic]]
[[Category: Structural genomic]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 01:59:47 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Jul 27 14:44:53 2008''

Revision as of 11:45, 27 July 2008

Image:1n27.png

Template:STRUCTURE 1n27

Solution structure of the PWWP domain of mouse Hepatoma-derived growth factor, related protein 3

Template:ABSTRACT PUBMED 15689505

About this Structure

1N27 is a Single protein structure of sequence from Mus musculus. Full experimental information is available from OCA.

Reference

Solution structure of the PWWP domain of the hepatoma-derived growth factor family., Nameki N, Tochio N, Koshiba S, Inoue M, Yabuki T, Aoki M, Seki E, Matsuda T, Fujikura Y, Saito M, Ikari M, Watanabe M, Terada T, Shirouzu M, Yoshida M, Hirota H, Tanaka A, Hayashizaki Y, Guntert P, Kigawa T, Yokoyama S, Protein Sci. 2005 Mar;14(3):756-64. Epub 2005 Feb 2. PMID:15689505

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