1n35

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[[Image:1n35.gif|left|200px]]
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[[Image:1n35.png|left|200px]]
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{{STRUCTURE_1n35| PDB=1n35 | SCENE= }}
{{STRUCTURE_1n35| PDB=1n35 | SCENE= }}
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'''lambda3 elongation complex with four phosphodiester bond formed'''
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===lambda3 elongation complex with four phosphodiester bond formed===
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==Overview==
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The reovirus polymerase and those of other dsRNA viruses function within the confines of a protein capsid to transcribe the tightly packed dsRNA genome segments. The crystal structure of the reovirus polymerase, lambda3, determined at 2.5 A resolution, shows a fingers-palm-thumb core, similar to those of other viral polymerases, surrounded by major N- and C-terminal elaborations, which create a cage-like structure, with four channels leading to the catalytic site. This "caged" polymerase has allowed us to visualize the results of several rounds of RNA polymerization directly in the crystals. A 5' cap binding site on the surface of lambda3 suggests a template retention mechanism by which attachment of the 5' end of the plus-sense strand facilitates insertion of the 3' end of the minus-sense strand into the template channel.
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The line below this paragraph, {{ABSTRACT_PUBMED_12464184}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 12464184 is the PubMed ID number.
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{{ABSTRACT_PUBMED_12464184}}
==About this Structure==
==About this Structure==
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[[Category: Right hand configuration]]
[[Category: Right hand configuration]]
[[Category: Rna polymerase]]
[[Category: Rna polymerase]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 02:01:54 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 08:09:25 2008''

Revision as of 05:09, 29 July 2008

Image:1n35.png

Template:STRUCTURE 1n35

lambda3 elongation complex with four phosphodiester bond formed

Template:ABSTRACT PUBMED 12464184

About this Structure

1N35 is a Single protein structure of sequence from Mammalian orthoreovirus 3. Full crystallographic information is available from OCA.

Reference

RNA synthesis in a cage--structural studies of reovirus polymerase lambda3., Tao Y, Farsetta DL, Nibert ML, Harrison SC, Cell. 2002 Nov 27;111(5):733-45. PMID:12464184

Page seeded by OCA on Tue Jul 29 08:09:25 2008

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