1n6g

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[[Image:1n6g.gif|left|200px]]
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{{Seed}}
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[[Image:1n6g.png|left|200px]]
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{{STRUCTURE_1n6g| PDB=1n6g | SCENE= }}
{{STRUCTURE_1n6g| PDB=1n6g | SCENE= }}
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'''The structure of immature Dengue-2 prM particles'''
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===The structure of immature Dengue-2 prM particles===
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==Overview==
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Structures of prM-containing dengue and yellow fever virus particles were determined to 16 and 25 A resolution, respectively, by cryoelectron microscopy and image reconstruction techniques. The closely similar structures show 60 icosahedrally organized trimeric spikes on the particle surface. Each spike consists of three prM:E heterodimers, where E is an envelope glycoprotein and prM is the precursor to the membrane protein M. The pre-peptide components of the prM proteins in each spike cover the fusion peptides at the distal ends of the E glycoproteins in a manner similar to the organization of the glycoproteins in the alphavirus spikes. Each heterodimer is associated with an E and a prM transmembrane density. These transmembrane densities represent either an EE or prMprM antiparallel coiled coil by which each protein spans the membrane twice, leaving the C-terminus of each protein on the exterior of the viral membrane, consistent with the predicted membrane-spanning domains of the unprocessed polyprotein.
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The line below this paragraph, {{ABSTRACT_PUBMED_12773377}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 12773377 is the PubMed ID number.
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{{ABSTRACT_PUBMED_12773377}}
==About this Structure==
==About this Structure==
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[[Category: Icosahedral virus]]
[[Category: Icosahedral virus]]
[[Category: Prm particle]]
[[Category: Prm particle]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 02:09:20 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jul 23 07:58:47 2008''

Revision as of 04:58, 23 July 2008

Image:1n6g.png

Template:STRUCTURE 1n6g

The structure of immature Dengue-2 prM particles

Template:ABSTRACT PUBMED 12773377

About this Structure

1N6G is a Single protein structure of sequence from Dengue virus 2. Full crystallographic information is available from OCA.

Reference

Structures of immature flavivirus particles., Zhang Y, Corver J, Chipman PR, Zhang W, Pletnev SV, Sedlak D, Baker TS, Strauss JH, Kuhn RJ, Rossmann MG, EMBO J. 2003 Jun 2;22(11):2604-13. PMID:12773377

Page seeded by OCA on Wed Jul 23 07:58:47 2008

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