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1n7i

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{{STRUCTURE_1n7i| PDB=1n7i | SCENE= }}
{{STRUCTURE_1n7i| PDB=1n7i | SCENE= }}
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'''The structure of Phenylethanolamine N-methyltransferase in complex with S-adenosylhomocysteine and the inhibitor LY134046'''
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===The structure of Phenylethanolamine N-methyltransferase in complex with S-adenosylhomocysteine and the inhibitor LY134046===
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==Overview==
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The crystal structures of human phenylethanolamine N-methyltransferase in complex with S-adenosyl-l-homocysteine (7, AdoHcy) and either 7-iodo-1,2,3,4-tetrahydroisoquinoline (2) or 8,9-dichloro-2,3,4,5-tetrahydro-1H-2-benzazepine (3, LY134046) were determined and compared with the structure of the enzyme complex with 7 and 7-aminosulfonyl-1,2,3,4-tetrahydroisoquinoline (1, SK&amp;F 29661). The enzyme is able to accommodate a variety of chemically disparate functional groups on the aromatic ring of the inhibitors through adaptation of the binding pocket for this substituent and by subtle adjustments of the orientation of the inhibitors within the relatively planar binding site. In addition, the interactions formed by the amine nitrogen of all three inhibitors reinforce the hypothesis that this functional group mimics the beta-hydroxyl of norepinephrine rather than the amine. These studies provide further clues for the development of improved inhibitors for use as pharmacological probes.
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(as it appears on PubMed at http://www.pubmed.gov), where 14695818 is the PubMed ID number.
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{{ABSTRACT_PUBMED_14695818}}
==About this Structure==
==About this Structure==
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[[Category: S-adenolsylhomocysteine]]
[[Category: S-adenolsylhomocysteine]]
[[Category: S-adenosylmethionine]]
[[Category: S-adenosylmethionine]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 02:11:32 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 15:21:41 2008''

Revision as of 12:21, 28 July 2008

Image:1n7i.png

Template:STRUCTURE 1n7i

The structure of Phenylethanolamine N-methyltransferase in complex with S-adenosylhomocysteine and the inhibitor LY134046

Template:ABSTRACT PUBMED 14695818

About this Structure

1N7I is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Molecular recognition of sub-micromolar inhibitors by the epinephrine-synthesizing enzyme phenylethanolamine N-methyltransferase., McMillan FM, Archbold J, McLeish MJ, Caine JM, Criscione KR, Grunewald GL, Martin JL, J Med Chem. 2004 Jan 1;47(1):37-44. PMID:14695818

Page seeded by OCA on Mon Jul 28 15:21:41 2008

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