1n8j

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[[Image:1n8j.gif|left|200px]]
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{{Seed}}
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{{STRUCTURE_1n8j| PDB=1n8j | SCENE= }}
{{STRUCTURE_1n8j| PDB=1n8j | SCENE= }}
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'''Crystal Structure of AhpC with Active Site Cysteine mutated to Serine (C46S)'''
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===Crystal Structure of AhpC with Active Site Cysteine mutated to Serine (C46S)===
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==Overview==
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Eukaryotic 2-Cys peroxiredoxins (2-Cys Prxs) not only act as antioxidants, but also appear to regulate hydrogen peroxide-mediated signal transduction. We show that bacterial 2-Cys Prxs are much less sensitive to oxidative inactivation than are eukaryotic 2-Cys Prxs. By identifying two sequence motifs unique to the sensitive 2-Cys Prxs and comparing the crystal structure of a bacterial 2-Cys Prx at 2.2 angstrom resolution with other Prx structures, we define the structural origins of sensitivity. We suggest this adaptation allows 2-Cys Prxs to act as floodgates, keeping resting levels of hydrogen peroxide low, while permitting higher levels during signal transduction.
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(as it appears on PubMed at http://www.pubmed.gov), where 12714747 is the PubMed ID number.
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{{ABSTRACT_PUBMED_12714747}}
==About this Structure==
==About this Structure==
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[[Category: Peroxidase]]
[[Category: Peroxidase]]
[[Category: Peroxiredoxin]]
[[Category: Peroxiredoxin]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 02:13:38 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Jul 27 16:31:05 2008''

Revision as of 13:31, 27 July 2008

Image:1n8j.png

Template:STRUCTURE 1n8j

Crystal Structure of AhpC with Active Site Cysteine mutated to Serine (C46S)

Template:ABSTRACT PUBMED 12714747

About this Structure

1N8J is a Single protein structure of sequence from Salmonella typhimurium. Full crystallographic information is available from OCA.

Reference

Peroxiredoxin evolution and the regulation of hydrogen peroxide signaling., Wood ZA, Poole LB, Karplus PA, Science. 2003 Apr 25;300(5619):650-3. PMID:12714747

Page seeded by OCA on Sun Jul 27 16:31:05 2008

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