1n8s

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{{Seed}}
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{{STRUCTURE_1n8s| PDB=1n8s | SCENE= }}
{{STRUCTURE_1n8s| PDB=1n8s | SCENE= }}
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'''Structure of the pancreatic lipase-colipase complex'''
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===Structure of the pancreatic lipase-colipase complex===
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==Overview==
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Interfacial adsorption of pancreatic lipase is strongly dependent on the physical chemical properties of the lipid surface. These properties are affected by amphiphiles such as phospholipids and bile salts. In the presence of such amphiphiles, lipase binding to the interface requires a protein cofactor, colipase. We obtained crystals of the pancreatic lipase-procolipase complex and solved the structure at 3.04 A resolution. Here we describe the structure of procolipase, which essentially consists of three 'fingers' and is topologically comparable to snake toxins. The tips of the fingers contain most of the hydrophobic amino acids and presumably form the interfacial binding site. Lipase binding occurs at the opposite side to this site and involves polar interactions. Determination of the three-dimensional structure of pancreatic lipase has revealed the presence of two domains: an amino-terminal domain, at residues 1-336 containing the active site and a carboxy-terminal domain at residues 337-449 (ref. 6). Procolipase binds exclusively to the C-terminal domain of lipase. No conformational change in the lipase molecule is induced by the binding of procolipase.
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The line below this paragraph, {{ABSTRACT_PUBMED_1522902}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 1522902 is the PubMed ID number.
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{{ABSTRACT_PUBMED_1522902}}
==About this Structure==
==About this Structure==
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[[Category: Pancrea]]
[[Category: Pancrea]]
[[Category: Signal]]
[[Category: Signal]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 02:14:10 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 12:13:25 2008''

Revision as of 09:13, 28 July 2008

Image:1n8s.png

Template:STRUCTURE 1n8s

Structure of the pancreatic lipase-colipase complex

Template:ABSTRACT PUBMED 1522902

About this Structure

1N8S is a Protein complex structure of sequences from Homo sapiens and Sus scrofa. Full crystallographic information is available from OCA.

Reference

Structure of the pancreatic lipase-procolipase complex., van Tilbeurgh H, Sarda L, Verger R, Cambillau C, Nature. 1992 Sep 10;359(6391):159-62. PMID:1522902

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