1nbf

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[[Image:1nbf.gif|left|200px]]
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{{Seed}}
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{{STRUCTURE_1nbf| PDB=1nbf | SCENE= }}
{{STRUCTURE_1nbf| PDB=1nbf | SCENE= }}
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'''Crystal structure of a UBP-family deubiquitinating enzyme in isolation and in complex with ubiquitin aldehyde'''
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===Crystal structure of a UBP-family deubiquitinating enzyme in isolation and in complex with ubiquitin aldehyde===
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==Overview==
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The ubiquitin-specific processing protease (UBP) family of deubiquitinating enzymes plays an essential role in numerous cellular processes. HAUSP, a representative UBP, specifically deubiquitinates and hence stabilizes the tumor suppressor protein p53. Here, we report the crystal structures of the 40 kDa catalytic core domain of HAUSP in isolation and in complex with ubiquitin aldehyde. These studies reveal that the UBP deubiquitinating enzymes exhibit a conserved three-domain architecture, comprising Fingers, Palm, and Thumb. The leaving ubiquitin moiety is specifically coordinated by the Fingers, with its C terminus placed in the active site between the Palm and the Thumb. Binding by ubiquitin aldehyde induces a drastic conformational change in the active site that realigns the catalytic triad residues for catalysis.
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The line below this paragraph, {{ABSTRACT_PUBMED_12507430}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 12507430 is the PubMed ID number.
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{{ABSTRACT_PUBMED_12507430}}
==About this Structure==
==About this Structure==
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[[Category: Hausp]]
[[Category: Hausp]]
[[Category: Ubiquitin binding]]
[[Category: Ubiquitin binding]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 02:19:52 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 00:39:33 2008''

Revision as of 21:39, 28 July 2008

Image:1nbf.png

Template:STRUCTURE 1nbf

Crystal structure of a UBP-family deubiquitinating enzyme in isolation and in complex with ubiquitin aldehyde

Template:ABSTRACT PUBMED 12507430

About this Structure

1NBF is a Protein complex structure of sequences from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Crystal structure of a UBP-family deubiquitinating enzyme in isolation and in complex with ubiquitin aldehyde., Hu M, Li P, Li M, Li W, Yao T, Wu JW, Gu W, Cohen RE, Shi Y, Cell. 2002 Dec 27;111(7):1041-54. PMID:12507430

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