8tub

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'''Unreleased structure'''
 
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The entry 8tub is ON HOLD until Paper Publication
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==HLA B7:02 with HPNGYKSLSTL==
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<StructureSection load='8tub' size='340' side='right'caption='[[8tub]], [[Resolution|resolution]] 2.40&Aring;' scene=''>
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Authors: Littler, D.R., Rossjohn, J., Chaurasia, P., Petersen, J.
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== Structural highlights ==
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<table><tr><td colspan='2'>[[8tub]] is a 12 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Influenza_B_virus Influenza B virus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8TUB OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8TUB FirstGlance]. <br>
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Description: HLA B7:02 with HPNGYKSLSTL
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.4&#8491;</td></tr>
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[[Category: Unreleased Structures]]
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=PEG:DI(HYDROXYETHYL)ETHER'>PEG</scene></td></tr>
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[[Category: Rossjohn, J]]
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8tub FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8tub OCA], [https://pdbe.org/8tub PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8tub RCSB], [https://www.ebi.ac.uk/pdbsum/8tub PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8tub ProSAT]</span></td></tr>
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[[Category: Petersen, J]]
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</table>
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[[Category: Chaurasia, P]]
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== Disease ==
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[[Category: Littler, D.R]]
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[https://www.uniprot.org/uniprot/B2MG_HUMAN B2MG_HUMAN] Defects in B2M are the cause of hypercatabolic hypoproteinemia (HYCATHYP) [MIM:[https://omim.org/entry/241600 241600]. Affected individuals show marked reduction in serum concentrations of immunoglobulin and albumin, probably due to rapid degradation.<ref>PMID:16549777</ref> Note=Beta-2-microglobulin may adopt the fibrillar configuration of amyloid in certain pathologic states. The capacity to assemble into amyloid fibrils is concentration dependent. Persistently high beta(2)-microglobulin serum levels lead to amyloidosis in patients on long-term hemodialysis.<ref>PMID:3532124</ref> <ref>PMID:1336137</ref> <ref>PMID:7554280</ref> <ref>PMID:4586824</ref> <ref>PMID:8084451</ref> <ref>PMID:12119416</ref> <ref>PMID:12796775</ref> <ref>PMID:16901902</ref> <ref>PMID:16491088</ref> <ref>PMID:17646174</ref> <ref>PMID:18835253</ref> <ref>PMID:18395224</ref> <ref>PMID:19284997</ref>
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== Function ==
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[https://www.uniprot.org/uniprot/B2MG_HUMAN B2MG_HUMAN] Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system.
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Homo sapiens]]
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[[Category: Influenza B virus]]
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[[Category: Large Structures]]
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[[Category: Chaurasia P]]
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[[Category: Littler DR]]
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[[Category: Petersen J]]
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[[Category: Rossjohn J]]

Revision as of 13:18, 13 March 2024

HLA B7:02 with HPNGYKSLSTL

PDB ID 8tub

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