8u1z
From Proteopedia
(Difference between revisions)
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| - | '''Unreleased structure''' | ||
| - | + | ==Crystal structure of the Fis1 cytosolic domain bound to a peptide inhibitor== | |
| - | + | <StructureSection load='8u1z' size='340' side='right'caption='[[8u1z]], [[Resolution|resolution]] 1.85Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[8u1z]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Synthetic_construct Synthetic construct]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8U1Z OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8U1Z FirstGlance]. <br> | |
| - | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.85Å</td></tr> | |
| - | [[Category: | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8u1z FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8u1z OCA], [https://pdbe.org/8u1z PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8u1z RCSB], [https://www.ebi.ac.uk/pdbsum/8u1z PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8u1z ProSAT]</span></td></tr> |
| + | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/FIS1_HUMAN FIS1_HUMAN] Promotes the fragmentation of the mitochondrial network and its perinuclear clustering. Can induce cytochrome c release from the mitochondrion to the cytosol, ultimately leading to apoptosis. Also mediates peroxisomal fission.<ref>PMID:12783892</ref> <ref>PMID:12861026</ref> <ref>PMID:14996942</ref> <ref>PMID:16118244</ref> <ref>PMID:16107562</ref> | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Homo sapiens]] | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Synthetic construct]] | ||
| + | [[Category: Hill RB]] | ||
| + | [[Category: Nolden KA]] | ||
| + | [[Category: Peterson FC]] | ||
Current revision
Crystal structure of the Fis1 cytosolic domain bound to a peptide inhibitor
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