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From Proteopedia
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== Function == | == Function == | ||
[https://www.uniprot.org/uniprot/KBTB2_HUMAN KBTB2_HUMAN] Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that acts as a regulator of the insulin signaling pathway, modulating insulin sensitivity by limiting PIK3R1/p85alpha abundance in adipocytes. Targets PIK3R1, the regulatory subunit of phosphatidylinositol 3-kinase (PI3K), for 'Lys-48'-linked polyubiquitination and proteasome-mediated degradation.<ref>PMID:27708159</ref> | [https://www.uniprot.org/uniprot/KBTB2_HUMAN KBTB2_HUMAN] Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that acts as a regulator of the insulin signaling pathway, modulating insulin sensitivity by limiting PIK3R1/p85alpha abundance in adipocytes. Targets PIK3R1, the regulatory subunit of phosphatidylinositol 3-kinase (PI3K), for 'Lys-48'-linked polyubiquitination and proteasome-mediated degradation.<ref>PMID:27708159</ref> | ||
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| + | ==See Also== | ||
| + | *[[Ring box protein 3D structures|Ring box protein 3D structures]] | ||
| + | *[[Ubiquitin protein ligase 3D structures|Ubiquitin protein ligase 3D structures]] | ||
== References == | == References == | ||
<references/> | <references/> | ||
Current revision
Cryo-EM Structure of the KBTBD2-Cul3-Rbx1 tetrameric complex
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Categories: Homo sapiens | Large Structures | Chen Z | Hu Y | Mao Q | Sun L
