8h4r
From Proteopedia
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8h4r FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8h4r OCA], [https://pdbe.org/8h4r PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8h4r RCSB], [https://www.ebi.ac.uk/pdbsum/8h4r PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8h4r ProSAT]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8h4r FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8h4r OCA], [https://pdbe.org/8h4r PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8h4r RCSB], [https://www.ebi.ac.uk/pdbsum/8h4r PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8h4r ProSAT]</span></td></tr> | ||
</table> | </table> | ||
| - | == Function == | ||
| - | [https://www.uniprot.org/uniprot/GST26_SCHJA GST26_SCHJA] Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles. GST isoenzymes appear to play a central role in the parasite detoxification system. Other functions are also suspected including a role in increasing the solubility of haematin in the parasite gut.[https://www.uniprot.org/uniprot/CDK3_HUMAN CDK3_HUMAN] Serine/threonine-protein kinase that plays a critical role in the control of the eukaryotic cell cycle; involved in G0-G1 and G1-S cell cycle transitions. Interacts with CCNC/cyclin-C during interphase. Phosphorylates histone H1, ATF1, RB1 and CABLES1. ATF1 phosphorylation triggers ATF1 transactivation and transcriptional activities, and promotes cell proliferation and transformation. CDK3/cyclin-C mediated RB1 phosphorylation is required for G0-G1 transition. Promotes G1-S transition probably by contributing to the activation of E2F1, E2F2 and E2F3 in a RB1-independent manner.<ref>PMID:15084261</ref> <ref>PMID:18794154</ref> <ref>PMID:8846921</ref> | ||
| - | == References == | ||
| - | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
Current revision
The Crystal Structure of CDK3 and CyclinE1 Complex with Dinaciclib from Biortus
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Categories: Homo sapiens | Large Structures | Schistosoma japonicum | Cheng W | Gao J | Gui W | Huang Y | Ouyang Z | Wang F
