1ndg

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{{STRUCTURE_1ndg| PDB=1ndg | SCENE= }}
{{STRUCTURE_1ndg| PDB=1ndg | SCENE= }}
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'''Crystal structure of Fab fragment of antibody HyHEL-8 complexed with its antigen lysozyme'''
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===Crystal structure of Fab fragment of antibody HyHEL-8 complexed with its antigen lysozyme===
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==Overview==
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The process whereby the immune system generates antibodies of higher affinities during a response to antigen (affinity maturation) is a prototypical example of molecular evolution. Earlier studies have been confined to antibodies specific for small molecules (haptens) rather than for proteins. We compare the structures of four antibodies bound to the same site on hen egg white lysozyme (HEL) at different stages of affinity maturation. These X-ray snapshots reveal that binding is enhanced, not through the formation of additional hydrogen bonds or van der Waals contacts or by an increase in total buried surface, but by burial of increasing amounts of apolar surface at the expense of polar surface, accompanied by improved shape complementarity. The increase in hydrophobic interactions results from highly correlated rearrangements in antibody residues at the interface periphery, adjacent to the central energetic hot spot. This first visualization of the maturation of antibodies to protein provides insights into the evolution of high affinity in other protein-protein interfaces.
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(as it appears on PubMed at http://www.pubmed.gov), where 12740607 is the PubMed ID number.
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{{ABSTRACT_PUBMED_12740607}}
==About this Structure==
==About this Structure==
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[[Category: Lysozyme]]
[[Category: Lysozyme]]
[[Category: Mutant]]
[[Category: Mutant]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 02:24:12 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 14:10:33 2008''

Revision as of 11:10, 28 July 2008

Image:1ndg.png

Template:STRUCTURE 1ndg

Crystal structure of Fab fragment of antibody HyHEL-8 complexed with its antigen lysozyme

Template:ABSTRACT PUBMED 12740607

About this Structure

1NDG is a Protein complex structure of sequences from Gallus gallus and Mus musculus. Full crystallographic information is available from OCA.

Reference

X-ray snapshots of the maturation of an antibody response to a protein antigen., Li Y, Li H, Yang F, Smith-Gill SJ, Mariuzza RA, Nat Struct Biol. 2003 Jun;10(6):482-8. PMID:12740607

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