1ndk

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Line 1: Line 1:
-
[[Image:1ndk.jpg|left|200px]]
+
{{Seed}}
 +
[[Image:1ndk.png|left|200px]]
<!--
<!--
Line 9: Line 10:
{{STRUCTURE_1ndk| PDB=1ndk | SCENE= }}
{{STRUCTURE_1ndk| PDB=1ndk | SCENE= }}
-
'''X-RAY STRUCTURE OF NUCLEOSIDE DIPHOSPHATE KINASE'''
+
===X-RAY STRUCTURE OF NUCLEOSIDE DIPHOSPHATE KINASE===
-
==Overview==
+
<!--
-
The X-ray structure of a point mutant of nucleoside diphosphate kinase (NDP kinase) from Dictyostelium discoideum has been determined to 2.2 A resolution. The enzyme is a hexamer made of identical subunits with a novel mononucleotide binding fold. Each subunit contains an alpha/beta domain with a four stranded, antiparallel beta-sheet. The topology is different from adenylate kinase, but identical to the allosteric domain of Escherichia coli ATCase regulatory subunits, which bind mononucleotides at an equivalent position. Dimer contacts between NDP kinase subunits within the hexamer are similar to those in ATCase. Trimer contacts involve a large loop of polypeptide chain that bears the site of the Pro----Ser substitution in Killer of prune (K-pn) mutants of the highly homologous Drosophila enzyme. Properties of Drosophila NDP kinase, the product of the awd developmental gene, and of the human enzyme, the product of the nm23 genes in tumorigenesis, are discussed in view of the three-dimensional structure and of possible interactions of NDP kinase with other nucleotide binding proteins.
+
The line below this paragraph, {{ABSTRACT_PUBMED_1324167}}, adds the Publication Abstract to the page
 +
(as it appears on PubMed at http://www.pubmed.gov), where 1324167 is the PubMed ID number.
 +
-->
 +
{{ABSTRACT_PUBMED_1324167}}
==About this Structure==
==About this Structure==
Line 29: Line 33:
[[Category: Veron, M.]]
[[Category: Veron, M.]]
[[Category: Transferase]]
[[Category: Transferase]]
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 02:24:24 2008''
+
 
 +
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 16:12:00 2008''

Revision as of 13:12, 28 July 2008

Image:1ndk.png

Template:STRUCTURE 1ndk

X-RAY STRUCTURE OF NUCLEOSIDE DIPHOSPHATE KINASE

Template:ABSTRACT PUBMED 1324167

About this Structure

1NDK is a Single protein structure of sequence from Dictyostelium discoideum. Full crystallographic information is available from OCA.

Reference

X-ray structure of nucleoside diphosphate kinase., Dumas C, Lascu I, Morera S, Glaser P, Fourme R, Wallet V, Lacombe ML, Veron M, Janin J, EMBO J. 1992 Sep;11(9):3203-8. PMID:1324167

Page seeded by OCA on Mon Jul 28 16:12:00 2008

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/1ndk"
Personal tools