1nep

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Line 1: Line 1:
-
[[Image:1nep.gif|left|200px]]
+
{{Seed}}
 +
[[Image:1nep.png|left|200px]]
<!--
<!--
Line 9: Line 10:
{{STRUCTURE_1nep| PDB=1nep | SCENE= }}
{{STRUCTURE_1nep| PDB=1nep | SCENE= }}
-
'''Crystal Structure Analysis of the Bovine NPC2 (Niemann-Pick C2) Protein'''
+
===Crystal Structure Analysis of the Bovine NPC2 (Niemann-Pick C2) Protein===
-
==Overview==
+
<!--
-
Niemann-Pick disease type C2 (NP-C2) is a fatal hereditary disease characterized by accumulation of low-density lipoprotein-derived cholesterol in lysosomes. Here we report the 1.7-A resolution crystal structure of the cholesterol-binding protein deficient in this disease, NPC2, and the characterization of its ligand binding properties. Human NPC2 binds the cholesterol analog dehydroergosterol with submicromolar affinity at both acidic and neutral pH. NPC2 has an Ig-like fold stabilized by three disulfide bonds. The structure of the bovine protein reveals a loosely packed region penetrating from the surface into the hydrophobic core that forms adjacent small cavities with a total volume of approximately 160 A(3). We propose that this region represents the incipient cholesterol-binding site that dilates to accommodate an approximately 740-A(3) cholesterol molecule.
+
The line below this paragraph, {{ABSTRACT_PUBMED_12591954}}, adds the Publication Abstract to the page
 +
(as it appears on PubMed at http://www.pubmed.gov), where 12591954 is the PubMed ID number.
 +
-->
 +
{{ABSTRACT_PUBMED_12591954}}
==About this Structure==
==About this Structure==
Line 31: Line 35:
[[Category: Niemann-pick c2]]
[[Category: Niemann-pick c2]]
[[Category: Npc2]]
[[Category: Npc2]]
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 02:26:36 2008''
+
 
 +
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 06:32:24 2008''

Revision as of 03:32, 29 July 2008

Image:1nep.png

Template:STRUCTURE 1nep

Crystal Structure Analysis of the Bovine NPC2 (Niemann-Pick C2) Protein

Template:ABSTRACT PUBMED 12591954

About this Structure

1NEP is a Single protein structure of sequence from Bos taurus. Full crystallographic information is available from OCA.

Reference

Structure of a cholesterol-binding protein deficient in Niemann-Pick type C2 disease., Friedland N, Liou HL, Lobel P, Stock AM, Proc Natl Acad Sci U S A. 2003 Mar 4;100(5):2512-7. Epub 2003 Feb 18. PMID:12591954

Page seeded by OCA on Tue Jul 29 06:32:24 2008

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/1nep"
Personal tools