1nfn

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{{STRUCTURE_1nfn| PDB=1nfn | SCENE= }}
{{STRUCTURE_1nfn| PDB=1nfn | SCENE= }}
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'''APOLIPOPROTEIN E3 (APOE3)'''
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===APOLIPOPROTEIN E3 (APOE3)===
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==Overview==
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The defective binding of apolipoprotein (apo) E2 to lipoprotein receptors, an underlying cause of type III hyperlipoproteinemia, results from replacement of Arg 158 with Cys, disrupting the naturally occurring salt bridge between Asp 154 and Arg 158. A new bond between Asp 154 and Arg 150 is formed, shifting Arg 150 out of the receptor binding region. Elimination of the 154-150 salt bridge by site-directed mutagenesis of Asp 154 to Ala restored the receptor binding activity to near normal levels. The X-ray crystal structure of apoE2 Ala 154 demonstrated that Arg 150 was relocated within the receptor binding region. Our results demonstrate that defective binding of apoE2 occurs by a novel mechanism of the replacement of one salt bridge with another.
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{{ABSTRACT_PUBMED_8756331}}
==About this Structure==
==About this Structure==
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[[Category: Plasma protein]]
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[[Category: Vldl]]
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Revision as of 07:23, 28 July 2008

Image:1nfn.png

Template:STRUCTURE 1nfn

APOLIPOPROTEIN E3 (APOE3)

Template:ABSTRACT PUBMED 8756331

About this Structure

1NFN is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Novel mechanism for defective receptor binding of apolipoprotein E2 in type III hyperlipoproteinemia., Dong LM, Parkin S, Trakhanov SD, Rupp B, Simmons T, Arnold KS, Newhouse YM, Innerarity TL, Weisgraber KH, Nat Struct Biol. 1996 Aug;3(8):718-22. PMID:8756331

Page seeded by OCA on Mon Jul 28 10:23:22 2008

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