1nfv

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[[Image:1nfv.gif|left|200px]]
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{{STRUCTURE_1nfv| PDB=1nfv | SCENE= }}
{{STRUCTURE_1nfv| PDB=1nfv | SCENE= }}
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'''X-ray structure of Desulfovibrio desulfuricans bacterioferritin: the diiron centre in different catalytic states (as-isolated structure)'''
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===X-ray structure of Desulfovibrio desulfuricans bacterioferritin: the diiron centre in different catalytic states (as-isolated structure)===
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==Overview==
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The first crystal structure of a native di-iron center in an iron-storage protein (bacterio)ferritin is reported. The protein, isolated from the anaerobic bacterium Desulfovibrio desulfuricans, has the unique property of having Fe-coproporphyrin III as its heme cofactor. The three-dimensional structure of this bacterioferritin was determined in three distinct catalytic/redox states by X-ray crystallography (at 1.95, 2.05 and 2.35 A resolution), corresponding to different intermediates of the di-iron ferroxidase site. Conformational changes associated with these intermediates support the idea of a route for iron entry into the protein shell through a pore that passes through the di-iron center. Molecular surface and electrostatic potential calculations also suggest the presence of another ion channel, distant from the channels at the three- and four-fold axes proposed as points of entry for the iron atoms.
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(as it appears on PubMed at http://www.pubmed.gov), where 12627224 is the PubMed ID number.
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{{ABSTRACT_PUBMED_12627224}}
==About this Structure==
==About this Structure==
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[[Category: Diiron centre]]
[[Category: Diiron centre]]
[[Category: Haem fe-coproporphyrin iii cofactor]]
[[Category: Haem fe-coproporphyrin iii cofactor]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 02:28:57 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 05:28:44 2008''

Revision as of 02:28, 29 July 2008

Image:1nfv.png

Template:STRUCTURE 1nfv

X-ray structure of Desulfovibrio desulfuricans bacterioferritin: the diiron centre in different catalytic states (as-isolated structure)

Template:ABSTRACT PUBMED 12627224

About this Structure

1NFV is a Single protein structure of sequence from Desulfovibrio desulfuricans. Full crystallographic information is available from OCA.

Reference

The nature of the di-iron site in the bacterioferritin from Desulfovibrio desulfuricans., Macedo S, Romao CV, Mitchell E, Matias PM, Liu MY, Xavier AV, LeGall J, Teixeira M, Lindley P, Carrondo MA, Nat Struct Biol. 2003 Apr;10(4):285-90. PMID:12627224

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