6vmj
From Proteopedia
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6vmj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6vmj OCA], [https://pdbe.org/6vmj PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6vmj RCSB], [https://www.ebi.ac.uk/pdbsum/6vmj PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6vmj ProSAT]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6vmj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6vmj OCA], [https://pdbe.org/6vmj PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6vmj RCSB], [https://www.ebi.ac.uk/pdbsum/6vmj PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6vmj ProSAT]</span></td></tr> | ||
</table> | </table> | ||
| - | == Disease == | ||
| - | [https://www.uniprot.org/uniprot/CFAD_HUMAN CFAD_HUMAN] Defects in CFD are the cause of complement factor D deficiency (CFDD) [MIM:[https://omim.org/entry/613912 613912]. CFDD is an immunologic disorder characterized by increased susceptibility to bacterial infections, particularly Neisseria infections, due to a defect in the alternative complement pathway. | ||
| - | == Function == | ||
| - | [https://www.uniprot.org/uniprot/CFAD_HUMAN CFAD_HUMAN] Factor D cleaves factor B when the latter is complexed with factor C3b, activating the C3bbb complex, which then becomes the C3 convertase of the alternate pathway. Its function is homologous to that of C1s in the classical pathway. | ||
==See Also== | ==See Also== | ||
Current revision
Crystal structure of human Complement Factor D with anti-Factor D Fab 20D12
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