1ngw

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[[Image:1ngw.gif|left|200px]]
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{{Seed}}
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{{STRUCTURE_1ngw| PDB=1ngw | SCENE= }}
{{STRUCTURE_1ngw| PDB=1ngw | SCENE= }}
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'''Chimeric Affinity Matured Fab 7g12 complexed with mesoporphyrin'''
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===Chimeric Affinity Matured Fab 7g12 complexed with mesoporphyrin===
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==Overview==
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The crystal structure of the Michaelis complex between the Fab fragment of ferrochelatase antibody 7G12 and its substrate mesoporphyrin has been solved to 2.6-A resolution. The antibody-bound mesoporphyrin clearly adopts a nonplanar conformation and reveals that the antibody catalyzes the porphyrin metallation reaction by straining/distorting the bound substrate toward the transition-state configuration. The crystal structures of the Fab fragment of the germ-line precursor antibody to 7G12 and its complex with the hapten N-methylmesoporphyrin have also been solved. A comparison of these structures with the corresponding structures of the affinity-matured antibody 7G12 reveals the molecular mechanism by which the immune system evolves binding energy to catalyze this reaction.
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The line below this paragraph, {{ABSTRACT_PUBMED_12552112}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 12552112 is the PubMed ID number.
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{{ABSTRACT_PUBMED_12552112}}
==About this Structure==
==About this Structure==
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[[Category: Antigen binding fragment]]
[[Category: Antigen binding fragment]]
[[Category: Immunoglobulin]]
[[Category: Immunoglobulin]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 02:30:57 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 05:56:06 2008''

Revision as of 02:56, 28 July 2008

Image:1ngw.png

Template:STRUCTURE 1ngw

Chimeric Affinity Matured Fab 7g12 complexed with mesoporphyrin

Template:ABSTRACT PUBMED 12552112

About this Structure

1NGW is a Single protein structure of sequence from Mus musculus, homo sapiens. Full crystallographic information is available from OCA.

Reference

Structural evidence for substrate strain in antibody catalysis., Yin J, Andryski SE, Beuscher AE 4th, Stevens RC, Schultz PG, Proc Natl Acad Sci U S A. 2003 Feb 4;100(3):856-61. Epub 2003 Jan 24. PMID:12552112

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