8qt5
From Proteopedia
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| - | '''Unreleased structure''' | ||
| - | + | ==Crystal structure of Arabidopsis thaliana 14-3-3 isoform lambda in complex with a phosphopeptide from the transcription factor BZR1.== | |
| - | + | <StructureSection load='8qt5' size='340' side='right'caption='[[8qt5]], [[Resolution|resolution]] 2.69Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[8qt5]] is a 7 chain structure with sequence from [https://en.wikipedia.org/wiki/Arabidopsis_thaliana Arabidopsis thaliana]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8QT5 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8QT5 FirstGlance]. <br> | |
| - | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.69Å</td></tr> | |
| - | [[Category: | + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=SEP:PHOSPHOSERINE'>SEP</scene></td></tr> |
| - | [[Category: | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8qt5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8qt5 OCA], [https://pdbe.org/8qt5 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8qt5 RCSB], [https://www.ebi.ac.uk/pdbsum/8qt5 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8qt5 ProSAT]</span></td></tr> |
| - | [[Category: Hothorn | + | </table> |
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/14336_ARATH 14336_ARATH] Is associated with a DNA binding complex that binds to the G box, a well-characterized cis-acting DNA regulatory element found in plant genes (By similarity). Specific negative regulator of slow-vacuolar (SV) ion channel. Mediates F-actin dynamics possibly through inhibiting ADF1 phosphorylation (PubMed:26345162). Negative regulator of freezing tolerance that modulates cold-responsive C-repeat-binding factors (CBF) DREB1A and DREB1B proteins stability by facilitating their ubiquitin-mediated degradation when activated by CRPK1-mediated phosophorylation in freezing conditions; this processus is counteracted by B1L (PubMed:28344081, PubMed:31297122).<ref>PMID:17764516</ref> <ref>PMID:26345162</ref> <ref>PMID:28344081</ref> <ref>PMID:31297122</ref> [https://www.uniprot.org/uniprot/BZR1_ARATH BZR1_ARATH] Transcriptional repressor that binds to the brassinosteroid (BR) response element (BRRE) 5'-CGTG(T/C)G-3' in gene promoter. Regulates positively the brassinosteroid-signaling pathway (PubMed:33324437). Mediates downstream growth responses and negative feedback regulation of brassinosteroid biosynthesis. Promotes growth. Modulates ovule initiation and development by monitoring the expression of genes related to ovule development (e.g. HLL, ANT, and AP2). Regulates negatively the abscisic acid (ABA) signaling pathway during the post-germination stage (PubMed:33324437).<ref>PMID:15681342</ref> <ref>PMID:22914576</ref> <ref>PMID:33324437</ref> | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Arabidopsis thaliana]] | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Hothorn M]] | ||
| + | [[Category: Obergfell E]] | ||
Revision as of 07:08, 25 October 2023
Crystal structure of Arabidopsis thaliana 14-3-3 isoform lambda in complex with a phosphopeptide from the transcription factor BZR1.
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