8wr8
From Proteopedia
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| - | '''Unreleased structure''' | ||
| - | The | + | ==The Crystal Structure of cGAS from Biortus== |
| - | + | <StructureSection load='8wr8' size='340' side='right'caption='[[8wr8]], [[Resolution|resolution]] 3.10Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[8wr8]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8WR8 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8WR8 FirstGlance]. <br> | |
| - | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.1Å</td></tr> | |
| - | [[Category: | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8wr8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8wr8 OCA], [https://pdbe.org/8wr8 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8wr8 RCSB], [https://www.ebi.ac.uk/pdbsum/8wr8 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8wr8 ProSAT]</span></td></tr> |
| + | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/CGAS_HUMAN CGAS_HUMAN] Nucleotidyltransferase that catalyzes formation of cyclic GMP-AMP (cGAMP) from ATP and GTP and exhibits antiviral activity. Has antiviral activity by acting as a key cytosolic DNA sensor, the presence of DNA in the cytoplasm being a danger signal that triggers the immune responses. Binds cytosolic DNA directly, leading to activation and synthesis of cGAMP, a second messenger that binds to and activates TMEM173/STING, thereby triggering type-I interferon production.<ref>PMID:21478870</ref> <ref>PMID:23258413</ref> | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Homo sapiens]] | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Cheng W]] | ||
| + | [[Category: Guo S]] | ||
| + | [[Category: Lin D]] | ||
| + | [[Category: Wang F]] | ||
| + | [[Category: Yuan Z]] | ||
Revision as of 07:44, 15 November 2023
The Crystal Structure of cGAS from Biortus
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Categories: Homo sapiens | Large Structures | Cheng W | Guo S | Lin D | Wang F | Yuan Z
