1nj3

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{{STRUCTURE_1nj3| PDB=1nj3 | SCENE= }}
{{STRUCTURE_1nj3| PDB=1nj3 | SCENE= }}
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'''Structure and Ubiquitin Interactions of the Conserved NZF Domain of Npl4'''
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===Structure and Ubiquitin Interactions of the Conserved NZF Domain of Npl4===
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==Overview==
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Ubiquitylated proteins are directed into a large number of different cellular pathways through interactions with effector proteins that contain conserved ubiquitin binding motifs. Here, we report the solution structure and ubiquitin binding properties of one such motif, the Npl4 zinc finger or RanBP2/Nup358 zinc finger (NZF) domain. Npl4 NZF forms a compact module composed of four antiparallel beta-strands linked by three ordered loops. A single zinc ion is coordinated by four conserved cysteines from the first and third loops, which form two rubredoxin knuckles. Npl4 NZF binds specifically, but weakly, to free ubiquitin using a conserved 13TF14 dipeptide to interact with the "Ile-44" surface of ubiquitin. Our studies reveal the structure of this versatile class of protein binding domains and provide a means for identifying the subset of NZF domains likely to bind ubiquitin.
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{{ABSTRACT_PUBMED_12644454}}
==About this Structure==
==About this Structure==
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1NJ3 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1NJ3 OCA].
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1NJ3 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1NJ3 OCA].
==Reference==
==Reference==
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[[Category: Ubiquitin]]
[[Category: Ubiquitin]]
[[Category: Zinc-finger]]
[[Category: Zinc-finger]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 10:06:43 2008''

Revision as of 07:06, 29 July 2008

Image:1nj3.png

Template:STRUCTURE 1nj3

Structure and Ubiquitin Interactions of the Conserved NZF Domain of Npl4

Template:ABSTRACT PUBMED 12644454

About this Structure

1NJ3 is a Single protein structure of sequence from Rattus norvegicus. Full experimental information is available from OCA.

Reference

Structure and ubiquitin interactions of the conserved zinc finger domain of Npl4., Wang B, Alam SL, Meyer HH, Payne M, Stemmler TL, Davis DR, Sundquist WI, J Biol Chem. 2003 May 30;278(22):20225-34. Epub 2003 Mar 18. PMID:12644454

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