7kqg
From Proteopedia
(Difference between revisions)
| Line 8: | Line 8: | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7kqg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7kqg OCA], [https://pdbe.org/7kqg PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7kqg RCSB], [https://www.ebi.ac.uk/pdbsum/7kqg PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7kqg ProSAT]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7kqg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7kqg OCA], [https://pdbe.org/7kqg PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7kqg RCSB], [https://www.ebi.ac.uk/pdbsum/7kqg PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7kqg ProSAT]</span></td></tr> | ||
</table> | </table> | ||
| - | == Function == | ||
| - | [https://www.uniprot.org/uniprot/E1TVD5_9INFB E1TVD5_9INFB] Binds to sialic acid-containing receptors on the cell surface, bringing about the attachment of the virus particle to the cell. Plays a major role in the determination of host range restriction and virulence. Class I viral fusion protein. Responsible for penetration of the virus into the cell cytoplasm by mediating the fusion of the membrane of the endocytosed virus particle with the endosomal membrane. Low pH in endosomes induce an irreversible conformational change in HA2, releasing the fusion hydrophobic peptide. Several trimers are required to form a competent fusion pore.[ARBA:ARBA00002710] Binds to sialic acid-containing receptors on the cell surface, bringing about the attachment of the virus particle to the cell. This attachment induces virion internalization of about two third of the virus particles through clathrin-dependent endocytosis and about one third through a clathrin- and caveolin-independent pathway. Plays a major role in the determination of host range restriction and virulence. Class I viral fusion protein. Responsible for penetration of the virus into the cell cytoplasm by mediating the fusion of the membrane of the endocytosed virus particle with the endosomal membrane. Low pH in endosomes induces an irreversible conformational change in HA2, releasing the fusion hydrophobic peptide. Several trimers are required to form a competent fusion pore.[RuleBase:RU003324] | ||
<div style="background-color:#fffaf0;"> | <div style="background-color:#fffaf0;"> | ||
== Publication Abstract from PubMed == | == Publication Abstract from PubMed == | ||
Current revision
Antibodies that engage the hemagglutinin receptor-binding site of influenza B viruses
| |||||||||||
