1nks

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{{STRUCTURE_1nks| PDB=1nks | SCENE= }}
{{STRUCTURE_1nks| PDB=1nks | SCENE= }}
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'''ADENYLATE KINASE FROM SULFOLOBUS ACIDOCALDARIUS'''
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===ADENYLATE KINASE FROM SULFOLOBUS ACIDOCALDARIUS===
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==Overview==
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The adenylate kinase from the hyperthermophilic archaean species Sulfolobus acidocaldarius has been cloned, expressed in Escherichia coli, purified and crystallized. The crystal structure was elucidated by multiple isomorphous replacement and non-crystallographic density averaging. The structure was refined at 2.6 A (1 A=0.1 nm) resolution. The enzyme is trimeric, in contrast to previous solution measurements that suggested a dimeric structure, and in contrast to the vast majority of adenylate kinases, which are monomeric. In large parts of each subunit the chain fold resembles the known enzyme structure from eubacteria and eukaryotes although the sequence homology is negligible. Since the asymmetric unit contains two trimers with and without bound AMP at the AMP sites and with an ADP at one of the six ATP sites, the analysis shows the enzyme in several states. The conformational differences between these states resemble those of other adenylate kinases. Because of sequence homology, the structure presented provides a good model for the methanococcal adenylate kinases.
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{{ABSTRACT_PUBMED_9733648}}
==About this Structure==
==About this Structure==
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[[Category: Thermophilic]]
[[Category: Thermophilic]]
[[Category: Transferase]]
[[Category: Transferase]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 02:39:00 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 04:27:26 2008''

Revision as of 01:27, 28 July 2008

Image:1nks.png

Template:STRUCTURE 1nks

ADENYLATE KINASE FROM SULFOLOBUS ACIDOCALDARIUS

Template:ABSTRACT PUBMED 9733648

About this Structure

1NKS is a Single protein structure of sequence from Sulfolobus acidocaldarius. Full crystallographic information is available from OCA.

Reference

The structure of a trimeric archaeal adenylate kinase., Vonrhein C, Bonisch H, Schafer G, Schulz GE, J Mol Biol. 1998 Sep 11;282(1):167-79. PMID:9733648

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