1nl1

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Line 1: Line 1:
-
[[Image:1nl1.gif|left|200px]]
+
{{Seed}}
 +
[[Image:1nl1.png|left|200px]]
<!--
<!--
Line 9: Line 10:
{{STRUCTURE_1nl1| PDB=1nl1 | SCENE= }}
{{STRUCTURE_1nl1| PDB=1nl1 | SCENE= }}
-
'''BOVINE PROTHROMBIN FRAGMENT 1 IN COMPLEX WITH CALCIUM ION'''
+
===BOVINE PROTHROMBIN FRAGMENT 1 IN COMPLEX WITH CALCIUM ION===
-
==Overview==
+
<!--
-
In a calcium-dependent interaction critical for blood coagulation, vitamin K-dependent blood coagulation proteins bind cell membranes containing phosphatidylserine via gamma-carboxyglutamic acid-rich (Gla) domains. Gla domain-mediated protein-membrane interaction is required for generation of thrombin, the terminal enzyme in the coagulation cascade, on a physiologic time scale. We determined by X-ray crystallography and NMR spectroscopy the lysophosphatidylserine-binding site in the bovine prothrombin Gla domain. The serine head group binds Gla domain-bound calcium ions and Gla residues 17 and 21, fixed elements of the Gla domain fold, predicting the structural basis for phosphatidylserine specificity among Gla domains. Gla domains provide a unique mechanism for protein-phospholipid membrane interaction. Increasingly Gla domains are being identified in proteins unrelated to blood coagulation. Thus, this membrane-binding mechanism may be important in other physiologic processes.
+
The line below this paragraph, {{ABSTRACT_PUBMED_12923575}}, adds the Publication Abstract to the page
 +
(as it appears on PubMed at http://www.pubmed.gov), where 12923575 is the PubMed ID number.
 +
-->
 +
{{ABSTRACT_PUBMED_12923575}}
==About this Structure==
==About this Structure==
Line 29: Line 33:
[[Category: Seaton, B.]]
[[Category: Seaton, B.]]
[[Category: Hydrolase]]
[[Category: Hydrolase]]
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 02:39:36 2008''
+
 
 +
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 05:56:52 2008''

Revision as of 02:57, 28 July 2008

Image:1nl1.png

Template:STRUCTURE 1nl1

BOVINE PROTHROMBIN FRAGMENT 1 IN COMPLEX WITH CALCIUM ION

Template:ABSTRACT PUBMED 12923575

About this Structure

1NL1 is a Single protein structure of sequence from Bos taurus. Full crystallographic information is available from OCA.

Reference

Structural basis of membrane binding by Gla domains of vitamin K-dependent proteins., Huang M, Rigby AC, Morelli X, Grant MA, Huang G, Furie B, Seaton B, Furie BC, Nat Struct Biol. 2003 Sep;10(9):751-6. Epub 2003 Aug 17. PMID:12923575

Page seeded by OCA on Mon Jul 28 05:56:52 2008

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/1nl1"
Personal tools