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1nm3

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{{STRUCTURE_1nm3| PDB=1nm3 | SCENE= }}
{{STRUCTURE_1nm3| PDB=1nm3 | SCENE= }}
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'''Crystal structure of Heamophilus influenza hybrid-Prx5'''
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===Crystal structure of Heamophilus influenza hybrid-Prx5===
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==Overview==
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Cellular redox control is often mediated by oxidation and reduction of cysteine residues in the redox-sensitive proteins, where thioredoxin and glutaredoxin (Grx) play as electron donors for the oxidized proteins. Despite the importance of protein-protein interactions between the electron donor and acceptor proteins, there has been no structural information for the interaction of thioredoxin or Grx with natural target proteins. Here, we present the crystal structure of a novel Haemophilus influenza peroxiredoxin (Prx) hybrid Prx5 determined at 2.8-A resolution. The structure reveals that hybrid Prx5 forms a tightly associated tetramer where active sites of Prx and Grx domains of different monomers interact with each other. The Prx-Grx interface comprises specific charge interactions surrounded by weak interactions, providing insight into the target recognition mechanism of Grx. The tetrameric structure also exhibits a flexible active site and alternative Prx-Grx interactions, which appear to facilitate the electron transfer from Grx to Prx domain. Differences of electron donor binding surfaces in Prx proteins revealed by an analysis based on the structural information explain the electron donor specificities of various Prx proteins.
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(as it appears on PubMed at http://www.pubmed.gov), where 12529327 is the PubMed ID number.
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{{ABSTRACT_PUBMED_12529327}}
==About this Structure==
==About this Structure==
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[[Category: Hybrid]]
[[Category: Hybrid]]
[[Category: Peroxiredoxin]]
[[Category: Peroxiredoxin]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 02:41:38 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 13:54:50 2008''

Revision as of 10:55, 28 July 2008

Image:1nm3.png

Template:STRUCTURE 1nm3

Crystal structure of Heamophilus influenza hybrid-Prx5

Template:ABSTRACT PUBMED 12529327

About this Structure

1NM3 is a Single protein structure of sequence from Haemophilus influenzae. Full crystallographic information is available from OCA.

Reference

The tetrameric structure of Haemophilus influenza hybrid Prx5 reveals interactions between electron donor and acceptor proteins., Kim SJ, Woo JR, Hwang YS, Jeong DG, Shin DH, Kim K, Ryu SE, J Biol Chem. 2003 Mar 21;278(12):10790-8. Epub 2003 Jan 14. PMID:12529327

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