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1nm8

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{{STRUCTURE_1nm8| PDB=1nm8 | SCENE= }}
{{STRUCTURE_1nm8| PDB=1nm8 | SCENE= }}
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'''Structure of Human Carnitine Acetyltransferase: Molecular Basis for Fatty Acyl Transfer'''
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===Structure of Human Carnitine Acetyltransferase: Molecular Basis for Fatty Acyl Transfer===
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==Overview==
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Carnitine acyltransferases are a family of ubiquitous enzymes that play a pivotal role in cellular energy metabolism. We report here the x-ray structure of human carnitine acetyltransferase to a 1.6-A resolution. This structure reveals a monomeric protein of two equally sized alpha/beta domains. Each domain is shown to have a partially similar fold to other known but oligomeric enzymes that are also involved in group-transfer reactions. The unique monomeric arrangement of the two domains constitutes a central narrow active site tunnel, indicating a likely universal feature for all members of the carnitine acyltransferase family. Superimposition of the substrate complex of a related protein, dihydrolipoyl trans-acetylase, reveals that both substrates localize to the active site tunnel of human carnitine acetyltransferase, suggesting the location of the ligand binding sites for carnitine and coenzyme A. Most significantly, this structure provides critical insights into the molecular basis for fatty acyl chain transfer and a possible common mechanism among a wide range of acyltransferases utilizing a catalytic dyad.
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(as it appears on PubMed at http://www.pubmed.gov), where 12562770 is the PubMed ID number.
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{{ABSTRACT_PUBMED_12562770}}
==About this Structure==
==About this Structure==
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 02:42:04 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 15:13:25 2008''

Revision as of 12:13, 29 July 2008

Image:1nm8.png

Template:STRUCTURE 1nm8

Structure of Human Carnitine Acetyltransferase: Molecular Basis for Fatty Acyl Transfer

Template:ABSTRACT PUBMED 12562770

About this Structure

1NM8 is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Structure of human carnitine acetyltransferase. Molecular basis for fatty acyl transfer., Wu D, Govindasamy L, Lian W, Gu Y, Kukar T, Agbandje-McKenna M, McKenna R, J Biol Chem. 2003 Apr 11;278(15):13159-65. Epub 2003 Jan 31. PMID:12562770

Page seeded by OCA on Tue Jul 29 15:13:25 2008

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