1np9

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[[Image:1np9.gif|left|200px]]
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{{STRUCTURE_1np9| PDB=1np9 | SCENE= }}
{{STRUCTURE_1np9| PDB=1np9 | SCENE= }}
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'''Structure of the parallel-stranded DNA quadruplex d(TTAGGGA)4 containing the human telomeric repeat'''
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===Structure of the parallel-stranded DNA quadruplex d(TTAGGGA)4 containing the human telomeric repeat===
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==Overview==
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The structure of the intermolecular DNA quadruplex d(TTAGGGT)4, based on the human telomeric DNA sequence d(TTAGGG), has been determined in solution by NMR and restrained molecular dynamics simultations. The core GGG region forms a highly stable quadruplex with G-tetrads likely stabilised by K+ ions bound between tetrad plains. However, we have focused on the conformation of the adenines which differ considerably in base alignment, stability and dynamics from those in previously reported structures of d(AGGGT)4 and d(TAGGGT)4. We show unambiguously that the adenines of d(TTAGGGT)4 are involved in the formation of a relatively stable A-tetrad with well-defined glycosidic torsion angles (anti), hydrogen bonding network (adenine 6-NH2-adenine N1) defined by interbase NOEs, and base stacking interactions with the neighbouring G-tetrad. All of these structural features are apparent from NOE data involving both exchangeable and non-exchangeable protons. Thus, context-dependent effects appear to play some role in dictating preferred conformation, stability and dynamics. The structure of d(TTAGGGT)4 provides us with a model system for exploiting in the design of novel telomerase inhibitors that bind to and stabilise G-quadruplex structures.
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The line below this paragraph, {{ABSTRACT_PUBMED_12926351}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 12926351 is the PubMed ID number.
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{{ABSTRACT_PUBMED_12926351}}
==About this Structure==
==About this Structure==
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Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1NP9 OCA].
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Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1NP9 OCA].
==Reference==
==Reference==
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[[Category: Parallel-stranded quadruplex dna]]
[[Category: Parallel-stranded quadruplex dna]]
[[Category: Ttagggt repeat]]
[[Category: Ttagggt repeat]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 02:48:36 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Jul 27 20:50:34 2008''

Revision as of 17:50, 27 July 2008

Image:1np9.png

Template:STRUCTURE 1np9

Structure of the parallel-stranded DNA quadruplex d(TTAGGGA)4 containing the human telomeric repeat

Template:ABSTRACT PUBMED 12926351

About this Structure

Full experimental information is available from OCA.

Reference

Structure of the parallel-stranded DNA quadruplex d(TTAGGGT)4 containing the human telomeric repeat: evidence for A-tetrad formation from NMR and molecular dynamics simulations., Gavathiotis E, Searle MS, Org Biomol Chem. 2003 May 21;1(10):1650-6. PMID:12926351

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