1nt1

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Line 1: Line 1:
-
[[Image:1nt1.jpg|left|200px]]
+
{{Seed}}
 +
[[Image:1nt1.png|left|200px]]
<!--
<!--
Line 9: Line 10:
{{STRUCTURE_1nt1| PDB=1nt1 | SCENE= }}
{{STRUCTURE_1nt1| PDB=1nt1 | SCENE= }}
-
'''thrombin in complex with selective macrocyclic inhibitor'''
+
===thrombin in complex with selective macrocyclic inhibitor===
-
==Overview==
+
<!--
-
A series of potent and selective proline- and pyrazinone-based macrocyclic thrombin inhibitors is described. Detailed SAR studies led to the incorporation of specific functional groups in the tether that enhanced functional activity against thrombin and provided exquisite selectivity against trypsin and tPA. X-ray crystallography and molecular modeling studies revealed the inhibitor-enzyme interactions responsible for this selectivity.
+
The line below this paragraph, {{ABSTRACT_PUBMED_12873514}}, adds the Publication Abstract to the page
 +
(as it appears on PubMed at http://www.pubmed.gov), where 12873514 is the PubMed ID number.
 +
-->
 +
{{ABSTRACT_PUBMED_12873514}}
==About this Structure==
==About this Structure==
Line 37: Line 41:
[[Category: Young, M.]]
[[Category: Young, M.]]
[[Category: Thrombin inhibitor complex]]
[[Category: Thrombin inhibitor complex]]
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 02:56:37 2008''
+
 
 +
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Jul 27 18:58:38 2008''

Revision as of 15:58, 27 July 2008

Template:STRUCTURE 1nt1

thrombin in complex with selective macrocyclic inhibitor

Template:ABSTRACT PUBMED 12873514

About this Structure

1NT1 is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Design and synthesis of potent and selective macrocyclic thrombin inhibitors., Nantermet PG, Barrow JC, Newton CL, Pellicore JM, Young M, Lewis SD, Lucas BJ, Krueger JA, McMasters DR, Yan Y, Kuo LC, Vacca JP, Selnick HG, Bioorg Med Chem Lett. 2003 Aug 18;13(16):2781-4. PMID:12873514

Page seeded by OCA on Sun Jul 27 18:58:38 2008

Proteopedia Page Contributors and Editors (what is this?)

OCA

Personal tools