1oll
From Proteopedia
(New page: 200px<br /> <applet load="1oll" size="450" color="white" frame="true" align="right" spinBox="true" caption="1oll, resolution 1.93Å" /> '''EXTRACELLULAR REGIO...) |
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| - | [[Image:1oll.gif|left|200px]]<br /> | + | [[Image:1oll.gif|left|200px]]<br /><applet load="1oll" size="350" color="white" frame="true" align="right" spinBox="true" |
| - | <applet load="1oll" size=" | + | |
caption="1oll, resolution 1.93Å" /> | caption="1oll, resolution 1.93Å" /> | ||
'''EXTRACELLULAR REGION OF THE HUMAN RECEPTOR NKP46'''<br /> | '''EXTRACELLULAR REGION OF THE HUMAN RECEPTOR NKP46'''<br /> | ||
==Overview== | ==Overview== | ||
| - | NKp46, a natural killer (NK) cell-specific receptor, has been recently | + | NKp46, a natural killer (NK) cell-specific receptor, has been recently identified as one of the triggering receptors involved in NK cell activation mediated by non-HLA class I ligands. The structure of the NKp46 extracellular receptor region, here reported, consists of two Ig-like domains assembled similarly to leukocyte immunoglobulin-like receptors (LIRs) and killer inhibitory receptors (KIRs). The extensive NKp46 residue substitutions at sites structurally related to those mediating interaction with HLA antigens in LIRs and KIRs indicate that NKp46 recognition processes in vivo should involve non-HLA ligands. NKP46 is shown to stem from an ancestral KIR/LIR family. However, the absence of close paralogues, such as those found for LIR and KIR, indicates that NKp46 is the unique member of a distinct Ig-like subfamily and suggests a specific role, which appears to be maintained across primates and rodents. |
==About this Structure== | ==About this Structure== | ||
| - | 1OLL is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli] with EDO as [http://en.wikipedia.org/wiki/ligand ligand]. Full crystallographic information is available from [http:// | + | 1OLL is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli] with <scene name='pdbligand=EDO:'>EDO</scene> as [http://en.wikipedia.org/wiki/ligand ligand]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1OLL OCA]. |
==Reference== | ==Reference== | ||
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[[Category: nk cell triggering receptor]] | [[Category: nk cell triggering receptor]] | ||
| - | ''Page seeded by [http:// | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 14:19:00 2008'' |
Revision as of 12:19, 21 February 2008
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EXTRACELLULAR REGION OF THE HUMAN RECEPTOR NKP46
Overview
NKp46, a natural killer (NK) cell-specific receptor, has been recently identified as one of the triggering receptors involved in NK cell activation mediated by non-HLA class I ligands. The structure of the NKp46 extracellular receptor region, here reported, consists of two Ig-like domains assembled similarly to leukocyte immunoglobulin-like receptors (LIRs) and killer inhibitory receptors (KIRs). The extensive NKp46 residue substitutions at sites structurally related to those mediating interaction with HLA antigens in LIRs and KIRs indicate that NKp46 recognition processes in vivo should involve non-HLA ligands. NKP46 is shown to stem from an ancestral KIR/LIR family. However, the absence of close paralogues, such as those found for LIR and KIR, indicates that NKp46 is the unique member of a distinct Ig-like subfamily and suggests a specific role, which appears to be maintained across primates and rodents.
About this Structure
1OLL is a Single protein structure of sequence from Escherichia coli with as ligand. Full crystallographic information is available from OCA.
Reference
Structure of the human NK cell triggering receptor NKp46 ectodomain., Ponassi M, Cantoni C, Biassoni R, Conte R, Spallarossa A, Pesce A, Moretta A, Moretta L, Bolognesi M, Bordo D, Biochem Biophys Res Commun. 2003 Sep 19;309(2):317-23. PMID:12951052
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