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1ntb

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{{STRUCTURE_1ntb| PDB=1ntb | SCENE= }}
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'''2.9 A crystal structure of Streptomycin RNA-aptamer complex'''
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===2.9 A crystal structure of Streptomycin RNA-aptamer complex===
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==Overview==
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We describe a 2.9 A X-ray structure of a complex between the aminocyclitol antibiotic streptomycin and an in vitro selected RNA aptamer, solved using the anomalous diffraction properties of Ba cations. The RNA aptamer, which contains two asymmetric internal loops, adopts a distinct cation-stabilized fold involving a series of S-shaped backbone turns anchored by canonical and noncanonical pairs and triples. The streptomycin streptose ring is encapsulated by stacked arrays of bases from both loops at the elbow of the L-shaped RNA architecture. Specificity is defined by direct hydrogen bonds between all streptose functional groups and base edges that line the inner walls of the cylindrical binding pocket. By contrast, the majority of intermolecular interactions involve contacts to backbone phosphates in the published structure of streptomycin bound to the 16S rRNA.
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(as it appears on PubMed at http://www.pubmed.gov), where 12618190 is the PubMed ID number.
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{{ABSTRACT_PUBMED_12618190}}
==About this Structure==
==About this Structure==
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[[Category: Magnesium form]]
[[Category: Magnesium form]]
[[Category: Streptomycin rna-aptamer]]
[[Category: Streptomycin rna-aptamer]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 02:57:16 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 08:46:03 2008''

Revision as of 05:46, 28 July 2008

Image:1ntb.png

Template:STRUCTURE 1ntb

2.9 A crystal structure of Streptomycin RNA-aptamer complex

Template:ABSTRACT PUBMED 12618190

About this Structure

Full crystallographic information is available from OCA.

Reference

Encapsulating streptomycin within a small 40-mer RNA., Tereshko V, Skripkin E, Patel DJ, Chem Biol. 2003 Feb;10(2):175-87. PMID:12618190

Page seeded by OCA on Mon Jul 28 08:46:03 2008

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