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1nw1

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{{STRUCTURE_1nw1| PDB=1nw1 | SCENE= }}
{{STRUCTURE_1nw1| PDB=1nw1 | SCENE= }}
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'''Crystal Structure of Choline Kinase'''
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===Crystal Structure of Choline Kinase===
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==Overview==
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Choline kinase catalyzes the ATP-dependent phosphorylation of choline, the first committed step in the CDP-choline pathway for the biosynthesis of phosphatidylcholine. The 2.0 A crystal structure of a choline kinase from C. elegans (CKA-2) reveals that the enzyme is a homodimeric protein with each monomer organized into a two-domain fold. The structure is remarkably similar to those of protein kinases and aminoglycoside phosphotransferases, despite no significant similarity in amino acid sequence. Comparisons to the structures of other kinases suggest that ATP binds to CKA-2 in a pocket formed by highly conserved and catalytically important residues. In addition, a choline binding site is proposed to be near the ATP binding pocket and formed by several structurally flexible loops.
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(as it appears on PubMed at http://www.pubmed.gov), where 12791258 is the PubMed ID number.
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{{ABSTRACT_PUBMED_12791258}}
==About this Structure==
==About this Structure==
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[[Category: Phospholipid synthesis]]
[[Category: Phospholipid synthesis]]
[[Category: Protein kinase fold]]
[[Category: Protein kinase fold]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 14:33:56 2008''

Revision as of 11:33, 29 July 2008

Image:1nw1.png

Template:STRUCTURE 1nw1

Crystal Structure of Choline Kinase

Template:ABSTRACT PUBMED 12791258

About this Structure

1NW1 is a Single protein structure of sequence from Caenorhabditis elegans. Full crystallographic information is available from OCA.

Reference

The crystal structure of choline kinase reveals a eukaryotic protein kinase fold., Peisach D, Gee P, Kent C, Xu Z, Structure. 2003 Jun;11(6):703-13. PMID:12791258

Page seeded by OCA on Tue Jul 29 14:33:56 2008

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