1nxm

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[[Image:1nxm.gif|left|200px]]
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{{STRUCTURE_1nxm| PDB=1nxm | SCENE= }}
{{STRUCTURE_1nxm| PDB=1nxm | SCENE= }}
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'''The high resolution structures of RmlC from Streptococcus suis'''
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===The high resolution structures of RmlC from Streptococcus suis===
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==Overview==
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Nature achieves the epimerization of carbohydrates by a variety of chemical routes. One common route is that performed by the class of enzyme defined by dTDP-6-deoxy-D-xylo-4-hexulose 3,5-epimerase (RmlC) from the rhamnose pathway. Earlier studies failed to identify the key residues in catalysis. We report the 1.3 A structure of RmlC from Streptococcus suis type 2 and its complexes with dTDP-D-glucose and dTDP-D-xylose. The streptococcal RmlC enzymes belong to a separate subgroup, sharing only 25% identity with RmlC from other bacteria, yet the S. suis enzyme has similar kinetic properties and structure to other RmlC enzymes. Structure, sequence alignment, and mutational analysis have now allowed reliable identification of the catalytic residues and their roles.
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(as it appears on PubMed at http://www.pubmed.gov), where 12791259 is the PubMed ID number.
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{{ABSTRACT_PUBMED_12791259}}
==About this Structure==
==About this Structure==
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[[Category: Beta sheet]]
[[Category: Beta sheet]]
[[Category: Jelly roll-like structure]]
[[Category: Jelly roll-like structure]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 03:06:00 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 12:48:52 2008''

Revision as of 09:48, 29 July 2008

Image:1nxm.png

Template:STRUCTURE 1nxm

The high resolution structures of RmlC from Streptococcus suis

Template:ABSTRACT PUBMED 12791259

About this Structure

1NXM is a Single protein structure of sequence from Streptococcus suis. Full crystallographic information is available from OCA.

Reference

High-resolution structures of RmlC from Streptococcus suis in complex with substrate analogs locate the active site of this class of enzyme., Dong C, Major LL, Allen A, Blankenfeldt W, Maskell D, Naismith JH, Structure. 2003 Jun;11(6):715-23. PMID:12791259

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