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1ny9

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{{STRUCTURE_1ny9| PDB=1ny9 | SCENE= }}
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'''Antibiotic binding domain of a TipA-class multidrug resistance transcriptional regulator'''
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===Antibiotic binding domain of a TipA-class multidrug resistance transcriptional regulator===
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==Overview==
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The TipAL protein, a bacterial transcriptional regulator of the MerR family, is activated by numerous cyclic thiopeptide antibiotics. Its C-terminal drug-binding domain, TipAS, defines a subfamily of broadly distributed bacterial proteins including Mta, a central regulator of multidrug resistance in Bacillus subtilis. The structure of apo TipAS, solved by solution NMR [Brookhaven Protein Data Bank entry 1NY9], is composed of a globin-like alpha-helical fold with a deep surface cleft and an unfolded N-terminal region. Antibiotics bind within the cleft at a position that is close to the corresponding heme pocket in myo- and hemoglobin, and induce folding of the N-terminus. Thus the classical globin fold is well adapted not only for accommodating its canonical cofactors, heme and other tetrapyrroles, but also for the recognition of a variety of antibiotics where ligand binding leads to transcriptional activation and drug resistance.
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{{ABSTRACT_PUBMED_12682015}}
==About this Structure==
==About this Structure==
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1NY9 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Streptomyces_lividans Streptomyces lividans]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1NY9 OCA].
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1NY9 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Streptomyces_lividans Streptomyces lividans]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1NY9 OCA].
==Reference==
==Reference==
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[[Category: All alpha]]
[[Category: All alpha]]
[[Category: Globin like]]
[[Category: Globin like]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 09:08:21 2008''

Revision as of 06:08, 28 July 2008

Image:1ny9.png

Template:STRUCTURE 1ny9

Antibiotic binding domain of a TipA-class multidrug resistance transcriptional regulator

Template:ABSTRACT PUBMED 12682015

About this Structure

1NY9 is a Single protein structure of sequence from Streptomyces lividans. Full experimental information is available from OCA.

Reference

Structural basis for antibiotic recognition by the TipA class of multidrug-resistance transcriptional regulators., Kahmann JD, Sass HJ, Allan MG, Seto H, Thompson CJ, Grzesiek S, EMBO J. 2003 Apr 15;22(8):1824-34. PMID:12682015

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