1nyb

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[[Image:1nyb.gif|left|200px]]
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{{STRUCTURE_1nyb| PDB=1nyb | SCENE= }}
{{STRUCTURE_1nyb| PDB=1nyb | SCENE= }}
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'''SOLUTION STRUCTURE OF THE BACTERIOPHAGE PHI21 N PEPTIDE-BOXB RNA COMPLEX'''
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===SOLUTION STRUCTURE OF THE BACTERIOPHAGE PHI21 N PEPTIDE-BOXB RNA COMPLEX===
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==Overview==
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We determined the solution structure of a 22-amino-acid peptide from the amino-terminal domain of the bacteriophage phi21 N protein in complex with its cognate 24-mer boxB RNA hairpin using heteronuclear magnetic resonance spectroscopy. The N peptide binds as an alpha-helix and interacts predominately with the major groove side of the 5' half of the boxB RNA stem-loop. This binding interface is defined by surface complementarity of polar and nonpolar interactions, and little sequence-specific recognition. The phi21 boxB loop (CUAACC) has hydrogen bond and backbone torsions typical of the "U-turn" motif, as well as base stacking of the last 4 nt, and a hydrogen bonded C:C pair closing the loop. The exposed face of the phi21 boxB loop, in complex with the N peptide, is strikingly similar to the GNRA tetraloop-like folds of the related lambda and P22 bacteriophage N peptide-boxB RNA complexes. The N peptide-boxB complexes of the various phage, while individually distinct, provide similar structural features for interactions with the Escherichia coli host factors to enable antitermination.
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{{ABSTRACT_PUBMED_12756325}}
==About this Structure==
==About this Structure==
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1NYB is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Enterobacteria_phage_phi21 Enterobacteria phage phi21]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1NYB OCA].
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1NYB is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Enterobacteria_phage_phi21 Enterobacteria phage phi21]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1NYB OCA].
==Reference==
==Reference==
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[[Category: Peptide-rna complex]]
[[Category: Peptide-rna complex]]
[[Category: Transcription antitermination]]
[[Category: Transcription antitermination]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 03:07:50 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 11:14:49 2008''

Revision as of 08:14, 29 July 2008

Image:1nyb.png

Template:STRUCTURE 1nyb

SOLUTION STRUCTURE OF THE BACTERIOPHAGE PHI21 N PEPTIDE-BOXB RNA COMPLEX

Template:ABSTRACT PUBMED 12756325

About this Structure

1NYB is a Single protein structure of sequence from Enterobacteria phage phi21. Full experimental information is available from OCA.

Reference

Structural mimicry in the phage phi21 N peptide-boxB RNA complex., Cilley CD, Williamson JR, RNA. 2003 Jun;9(6):663-76. PMID:12756325

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