1nyd

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[[Image:1nyd.gif|left|200px]]
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{{Seed}}
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{{STRUCTURE_1nyd| PDB=1nyd | SCENE= }}
{{STRUCTURE_1nyd| PDB=1nyd | SCENE= }}
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'''Solution structure of DNA quadruplex GCGGTGGAT'''
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===Solution structure of DNA quadruplex GCGGTGGAT===
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==Overview==
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The structure formed by the DNA sequence d(GCGGTGGAT) in a 100 mM Na(+) solution has been determined using molecular dynamics calculations constrained by distance and dihedral restraints derived from NMR experiments performed at isotopic natural abundance. The sequence folds into a dimer of dimers. Each symmetry-related half contains two parallel stranded G:G:G:G tetrads flanked by an A:A mismatch and by four-stranded G:C:G:C tetrads. Each of the two juxtaposed G:C:G:C tetrads is composed of alternating antiparallel strands from the two halves of the dimer. For each single strand, a thymine intersperses a double chain reversal connecting the juxtaposed G:G:G:G tetrads. This architecture has potential implications in genetic recombination. It suggests a pathway for oligomerization involving association of quadruplex entities through GpC steps.
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The line below this paragraph, {{ABSTRACT_PUBMED_14661946}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 14661946 is the PubMed ID number.
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{{ABSTRACT_PUBMED_14661946}}
==About this Structure==
==About this Structure==
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Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1NYD OCA].
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Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1NYD OCA].
==Reference==
==Reference==
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[[Category: Parallel quadruplex]]
[[Category: Parallel quadruplex]]
[[Category: Quadruplex]]
[[Category: Quadruplex]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 03:08:04 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Jul 27 20:27:51 2008''

Revision as of 17:27, 27 July 2008

Image:1nyd.png

Template:STRUCTURE 1nyd

Solution structure of DNA quadruplex GCGGTGGAT

Template:ABSTRACT PUBMED 14661946

About this Structure

Full experimental information is available from OCA.

Reference

Association of DNA quadruplexes through G:C:G:C tetrads. Solution structure of d(GCGGTGGAT)., Webba da Silva M, Biochemistry. 2003 Dec 16;42(49):14356-65. PMID:14661946

Page seeded by OCA on Sun Jul 27 20:27:51 2008

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