1nzc

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{{STRUCTURE_1nzc| PDB=1nzc | SCENE= }}
{{STRUCTURE_1nzc| PDB=1nzc | SCENE= }}
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'''The high resolution structures of RmlC from Streptococcus suis in complex with dTDP-D-xylose'''
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===The high resolution structures of RmlC from Streptococcus suis in complex with dTDP-D-xylose===
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==Overview==
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Nature achieves the epimerization of carbohydrates by a variety of chemical routes. One common route is that performed by the class of enzyme defined by dTDP-6-deoxy-D-xylo-4-hexulose 3,5-epimerase (RmlC) from the rhamnose pathway. Earlier studies failed to identify the key residues in catalysis. We report the 1.3 A structure of RmlC from Streptococcus suis type 2 and its complexes with dTDP-D-glucose and dTDP-D-xylose. The streptococcal RmlC enzymes belong to a separate subgroup, sharing only 25% identity with RmlC from other bacteria, yet the S. suis enzyme has similar kinetic properties and structure to other RmlC enzymes. Structure, sequence alignment, and mutational analysis have now allowed reliable identification of the catalytic residues and their roles.
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{{ABSTRACT_PUBMED_12791259}}
==About this Structure==
==About this Structure==
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[[Category: Beta sheet]]
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[[Category: Jelly roll-like structure]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 03:10:20 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 22:32:15 2008''

Revision as of 19:32, 28 July 2008

Image:1nzc.png

Template:STRUCTURE 1nzc

The high resolution structures of RmlC from Streptococcus suis in complex with dTDP-D-xylose

Template:ABSTRACT PUBMED 12791259

About this Structure

1NZC is a Single protein structure of sequence from Streptococcus suis. Full crystallographic information is available from OCA.

Reference

High-resolution structures of RmlC from Streptococcus suis in complex with substrate analogs locate the active site of this class of enzyme., Dong C, Major LL, Allen A, Blankenfeldt W, Maskell D, Naismith JH, Structure. 2003 Jun;11(6):715-23. PMID:12791259

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