This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.

Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.


1nzi

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Line 1: Line 1:
-
[[Image:1nzi.jpg|left|200px]]
+
{{Seed}}
 +
[[Image:1nzi.png|left|200px]]
<!--
<!--
Line 9: Line 10:
{{STRUCTURE_1nzi| PDB=1nzi | SCENE= }}
{{STRUCTURE_1nzi| PDB=1nzi | SCENE= }}
-
'''Crystal Structure of the CUB1-EGF Interaction Domain of Complement Protease C1s'''
+
===Crystal Structure of the CUB1-EGF Interaction Domain of Complement Protease C1s===
-
==Overview==
+
<!--
-
C1, the complex that triggers the classical pathway of complement, is assembled from two modular proteases C1r and C1s and a recognition protein C1q. The N-terminal CUB1-EGF segments of C1r and C1s are key elements of the C1 architecture, because they mediate both Ca2+-dependent C1r-C1s association and interaction with C1q. The crystal structure of the interaction domain of C1s has been solved and refined to 1.5 A resolution. The structure reveals a head-to-tail homodimer involving interactions between the CUB1 module of one monomer and the epidermal growth factor (EGF) module of its counterpart. A Ca2+ ion is bound to each EGF module and stabilizes both the intra- and inter-monomer interfaces. Unexpectedly, a second Ca2+ ion is bound to the distal end of each CUB1 module, through six ligands contributed by Glu45, Asp53, Asp98, and two water molecules. These acidic residues and Tyr17 are conserved in approximately two-thirds of the CUB repertoire and define a novel, Ca2+-binding CUB module subset. The C1s structure was used to build a model of the C1r-C1s CUB1-EGF heterodimer, which in C1 connects C1r to C1s and mediates interaction with C1q. A structural model of the C1q/C1r/C1s interface is proposed, where the rod-like collagen triple helix of C1q is accommodated into a groove along the transversal axis of the C1r-C1s heterodimer.
+
The line below this paragraph, {{ABSTRACT_PUBMED_12788922}}, adds the Publication Abstract to the page
 +
(as it appears on PubMed at http://www.pubmed.gov), where 12788922 is the PubMed ID number.
 +
-->
 +
{{ABSTRACT_PUBMED_12788922}}
==Disease==
==Disease==
Line 37: Line 41:
[[Category: Innate immunity]]
[[Category: Innate immunity]]
[[Category: Modular structure]]
[[Category: Modular structure]]
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 03:10:37 2008''
+
 
 +
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 08:08:40 2008''

Revision as of 05:08, 28 July 2008

Image:1nzi.png

Template:STRUCTURE 1nzi

Contents

Crystal Structure of the CUB1-EGF Interaction Domain of Complement Protease C1s

Template:ABSTRACT PUBMED 12788922

Disease

Known disease associated with this structure: C1r/C1s deficiency, combined OMIM:[120580], C1s deficiency, isolated OMIM:[120580]

About this Structure

1NZI is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

X-ray structure of the Ca2+-binding interaction domain of C1s. Insights into the assembly of the C1 complex of complement., Gregory LA, Thielens NM, Arlaud GJ, Fontecilla-Camps JC, Gaboriaud C, J Biol Chem. 2003 Aug 22;278(34):32157-64. Epub 2003 Jun 4. PMID:12788922

Page seeded by OCA on Mon Jul 28 08:08:40 2008

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/1nzi"
Personal tools