1nzs

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{{Seed}}
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{{STRUCTURE_1nzs| PDB=1nzs | SCENE= }}
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'''NMR structures of phosphorylated carboxy terminus of bovine rhodopsin in arrestin-bound state'''
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===NMR structures of phosphorylated carboxy terminus of bovine rhodopsin in arrestin-bound state===
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==Overview==
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Visual arrestin binds to the phosphorylated carboxy-terminal region of rhodopsin to block interactions with transducin and terminate signaling in the rod photoreceptor cells. A synthetic seven-phospho-peptide from the C-terminal region of rhodopsin, Rh(330-348), has been shown to bind arrestin and mimic inhibition of signal transduction. In this study, we examine conformational changes in this synthetic peptide upon binding to arrestin by high-resolution proton nuclear magnetic resonance (NMR). We show that the peptide is completely disordered in solution, but becomes structured upon binding to arrestin. A control, unphosphorylated peptide that fails to bind to arrestin remains highly disordered. Specific NMR distance constraints are used to model the arrestin-bound conformation. The models suggest that the phosphorylated carboxy-terminal region of rhodopsin, Rh(330-348), undergoes significant conformational changes and becomes structured upon binding to arrestin.
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(as it appears on PubMed at http://www.pubmed.gov), where 15111114 is the PubMed ID number.
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{{ABSTRACT_PUBMED_15111114}}
==About this Structure==
==About this Structure==
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1NZS is a [[Single protein]] structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1NZS OCA].
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1NZS is a [[Single protein]] structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1NZS OCA].
==Reference==
==Reference==
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[[Category: Rhodopsin]]
[[Category: Rhodopsin]]
[[Category: Signal termination]]
[[Category: Signal termination]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 03:11:23 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 08:09:16 2008''

Revision as of 05:09, 28 July 2008

Image:1nzs.png

Template:STRUCTURE 1nzs

NMR structures of phosphorylated carboxy terminus of bovine rhodopsin in arrestin-bound state

Template:ABSTRACT PUBMED 15111114

About this Structure

1NZS is a Single protein structure. Full experimental information is available from OCA.

Reference

The arrestin-bound conformation and dynamics of the phosphorylated carboxy-terminal region of rhodopsin., Kisselev OG, McDowell JH, Hargrave PA, FEBS Lett. 2004 Apr 30;564(3):307-11. PMID:15111114

Page seeded by OCA on Mon Jul 28 08:09:16 2008

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