2ke8
From Proteopedia
(Difference between revisions)
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2ke8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ke8 OCA], [https://pdbe.org/2ke8 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2ke8 RCSB], [https://www.ebi.ac.uk/pdbsum/2ke8 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2ke8 ProSAT]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2ke8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ke8 OCA], [https://pdbe.org/2ke8 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2ke8 RCSB], [https://www.ebi.ac.uk/pdbsum/2ke8 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2ke8 ProSAT]</span></td></tr> | ||
</table> | </table> | ||
| - | <div style="background-color:#fffaf0;"> | ||
| - | == Publication Abstract from PubMed == | ||
| - | Metal-mediated base pairs represent a powerful tool for the site-specific functionalization of nucleic acids with metal ions. The development of applications of the metal-modified nucleic acids will depend on the availability of structural information on these double helices. We present here the NMR solution structure of a self-complementary DNA oligonucleotide with three consecutive imidazole nucleotides in its centre. In the absence of transition-metal ions, a hairpin structure is adopted with the artificial nucleotides forming the loop. In the presence of Ag(i) ions, a duplex comprising three imidazole-Ag(+)-imidazole base pairs is formed. Direct proof for the formation of metal-mediated base pairs was obtained from (1)J((1)N,(1)/(1)Ag) couplings upon incorporation of (1)N-labelled imidazole. The duplex adopts a B-type conformation with only minor deviations in the region of the artificial bases. This work represents the first structural characterization of a metal-modified nucleic acid with a continuous stretch of metal-mediated base pairs. | ||
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| - | Solution structure of a DNA double helix with consecutive metal-mediated base pairs.,Johannsen S, Megger N, Bohme D, Sigel RK, Muller J Nat Chem. 2010 Mar;2(3):229-34. Epub 2010 Jan 17. PMID:21124482<ref>PMID:21124482</ref> | ||
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| - | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | ||
| - | </div> | ||
| - | <div class="pdbe-citations 2ke8" style="background-color:#fffaf0;"></div> | ||
| - | == References == | ||
| - | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
Current revision
NMR solution structure of metal-modified DNA
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