1o17

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{{STRUCTURE_1o17| PDB=1o17 | SCENE= }}
{{STRUCTURE_1o17| PDB=1o17 | SCENE= }}
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'''ANTHRANILATE PHOSPHORIBOSYL-TRANSFERASE (TRPD)'''
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===ANTHRANILATE PHOSPHORIBOSYL-TRANSFERASE (TRPD)===
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==Overview==
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The crystal structure of the dimeric anthranilate phosphoribosyltransferase (AnPRT) reveals a new category of phosphoribosyltransferases, designated as class III. The active site of this enzyme is located within the flexible hinge region of its two-domain structure. The pyrophosphate moiety of phosphoribosylpyrophosphate is co-ordinated by a metal ion and is bound by two conserved loop regions within this hinge region. With the structure of AnPRT available, structural analysis of all enzymatic activities of the tryptophan biosynthesis pathway is complete, thereby connecting the evolution of its enzyme members to the general development of metabolic processes. Its structure reveals it to have the same fold, topology, active site location and type of association as class II nucleoside phosphorylases. At the level of sequences, this relationship is mirrored by 13 structurally invariant residues common to both enzyme families. Taken together, these data imply common ancestry of enzymes catalysing reverse biological processes--the ribosylation and deribosylation of metabolic pathway intermediates. These relationships establish new links for enzymes involved in nucleotide and amino acid metabolism.
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The line below this paragraph, {{ABSTRACT_PUBMED_12093726}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 12093726 is the PubMed ID number.
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{{ABSTRACT_PUBMED_12093726}}
==About this Structure==
==About this Structure==
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[[Category: Wilmanns, M.]]
[[Category: Wilmanns, M.]]
[[Category: Nucleoside-phosphorylase]]
[[Category: Nucleoside-phosphorylase]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 03:13:49 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Jul 27 20:42:14 2008''

Revision as of 17:42, 27 July 2008

Image:1o17.png

Template:STRUCTURE 1o17

ANTHRANILATE PHOSPHORIBOSYL-TRANSFERASE (TRPD)

Template:ABSTRACT PUBMED 12093726

About this Structure

1O17 is a Single protein structure of sequence from Sulfolobus solfataricus. This structure supersedes the now removed PDB entry 1k8e. Full crystallographic information is available from OCA.

Reference

Structural analysis of two enzymes catalysing reverse metabolic reactions implies common ancestry., Mayans O, Ivens A, Nissen LJ, Kirschner K, Wilmanns M, EMBO J. 2002 Jul 1;21(13):3245-54. PMID:12093726

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