8ud7

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'''Unreleased structure'''
 
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The entry 8ud7 is ON HOLD until Paper Publication
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==Crystal structure of the A2058-N6-dimethylated Thermus thermophilus 70S ribosome in complex with cresomycin, mRNA, deacylated A-site tRNAphe, aminoacylated P-site fMet-tRNAmet, and deacylated E-site tRNAphe at 2.70A resolution==
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<StructureSection load='8ud7' size='340' side='right'caption='[[8ud7]], [[Resolution|resolution]] 2.55&Aring;' scene=''>
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Authors: Aleksandrova, E.V., Syroegin, E.A., Wu, K.J.Y., Tresco, B.I.C., Ramkissoon, A., See, D.N.Y., Liow, P., Dittemore, G.A., Yu, M., Testolin, G., Mitcheltree, M.J., Liu, R.Y., Svetlov, M.S., Myers, A.G., Polikanov, Y.S.
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== Structural highlights ==
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<table><tr><td colspan='2'>[[8ud7]] is a 20 chain structure with sequence from [https://en.wikipedia.org/wiki/Thermus_thermophilus_HB8 Thermus thermophilus HB8]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8UD7 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8UD7 FirstGlance]. <br>
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Description: Crystal structure of the A2058-N6-dimethylated Thermus thermophilus 70S ribosome in complex with cresomycin, mRNA, deacylated A-site tRNAphe, aminoacylated P-site fMet-tRNAmet, and deacylated E-site tRNAphe at 2.70A resolution
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.55&#8491;</td></tr>
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[[Category: Unreleased Structures]]
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=0TD:(3S)-3-(METHYLSULFANYL)-L-ASPARTIC+ACID'>0TD</scene>, <scene name='pdbligand=2MA:2-METHYLADENOSINE-5-MONOPHOSPHATE'>2MA</scene>, <scene name='pdbligand=2MG:2N-METHYLGUANOSINE-5-MONOPHOSPHATE'>2MG</scene>, <scene name='pdbligand=31H:3-DEOXY-3-[(N-FORMYL-L-METHIONYL)AMINO]ADENOSINE+5-(DIHYDROGEN+PHOSPHATE)'>31H</scene>, <scene name='pdbligand=4OC:4N,O2-METHYLCYTIDINE-5-MONOPHOSPHATE'>4OC</scene>, <scene name='pdbligand=4SU:4-THIOURIDINE-5-MONOPHOSPHATE'>4SU</scene>, <scene name='pdbligand=5MC:5-METHYLCYTIDINE-5-MONOPHOSPHATE'>5MC</scene>, <scene name='pdbligand=5MU:5-METHYLURIDINE+5-MONOPHOSPHATE'>5MU</scene>, <scene name='pdbligand=G7M:N7-METHYL-GUANOSINE-5-MONOPHOSPHATE'>G7M</scene>, <scene name='pdbligand=K:POTASSIUM+ION'>K</scene>, <scene name='pdbligand=M2G:N2-DIMETHYLGUANOSINE-5-MONOPHOSPHATE'>M2G</scene>, <scene name='pdbligand=MA6:6N-DIMETHYLADENOSINE-5-MONOPHOSHATE'>MA6</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=MIA:2-METHYLTHIO-N6-ISOPENTENYL-ADENOSINE-5-MONOPHOSPHATE'>MIA</scene>, <scene name='pdbligand=OMC:O2-METHYLYCYTIDINE-5-MONOPHOSPHATE'>OMC</scene>, <scene name='pdbligand=OMG:O2-METHYLGUANOSINE-5-MONOPHOSPHATE'>OMG</scene>, <scene name='pdbligand=OMU:O2-METHYLURIDINE+5-MONOPHOSPHATE'>OMU</scene>, <scene name='pdbligand=PSU:PSEUDOURIDINE-5-MONOPHOSPHATE'>PSU</scene>, <scene name='pdbligand=SF4:IRON/SULFUR+CLUSTER'>SF4</scene>, <scene name='pdbligand=UR3:3-METHYLURIDINE-5-MONOPHOSHATE'>UR3</scene>, <scene name='pdbligand=WC9:(4S,5aS,8S,8aR)-4-(2-methylpropyl)-N-[(1R,5Z,7R,8R,9R,10R,11S,12R)-10,11,12-trihydroxy-7-methyl-13-oxa-2-thiabicyclo[7.3.1]tridec-5-en-8-yl]octahydro-2H-oxepino[2,3-c]pyrrole-8-carboxamide+(non-preferred+name)'>WC9</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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[[Category: See, D.N.Y]]
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8ud7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8ud7 OCA], [https://pdbe.org/8ud7 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8ud7 RCSB], [https://www.ebi.ac.uk/pdbsum/8ud7 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8ud7 ProSAT]</span></td></tr>
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[[Category: Liow, P]]
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</table>
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[[Category: Polikanov, Y.S]]
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== Function ==
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[[Category: Mitcheltree, M.J]]
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[https://www.uniprot.org/uniprot/RL2_THET8 RL2_THET8] One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity; this is somewhat controversial (By similarity). Makes several contacts with the 16S rRNA (forming bridge B7b) in the 70S ribosome.[HAMAP-Rule:MF_01320_B]
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[[Category: Testolin, G]]
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__TOC__
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[[Category: Yu, M]]
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</StructureSection>
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[[Category: Syroegin, E.A]]
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[[Category: Large Structures]]
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[[Category: Svetlov, M.S]]
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[[Category: Thermus thermophilus HB8]]
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[[Category: Tresco, B.I.C]]
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[[Category: Aleksandrova EV]]
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[[Category: Liu, R.Y]]
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[[Category: Dittemore GA]]
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[[Category: Dittemore, G.A]]
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[[Category: Liow P]]
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[[Category: Ramkissoon, A]]
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[[Category: Liu RY]]
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[[Category: Wu, K.J.Y]]
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[[Category: Mitcheltree MJ]]
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[[Category: Myers, A.G]]
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[[Category: Myers AG]]
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[[Category: Aleksandrova, E.V]]
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[[Category: Polikanov YS]]
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[[Category: Ramkissoon A]]
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[[Category: See DNY]]
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[[Category: Svetlov MS]]
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[[Category: Syroegin EA]]
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[[Category: Testolin G]]
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[[Category: Tresco BIC]]
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[[Category: Wu KJY]]
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[[Category: Yu M]]

Revision as of 08:59, 21 February 2024

Crystal structure of the A2058-N6-dimethylated Thermus thermophilus 70S ribosome in complex with cresomycin, mRNA, deacylated A-site tRNAphe, aminoacylated P-site fMet-tRNAmet, and deacylated E-site tRNAphe at 2.70A resolution

PDB ID 8ud7

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OCA

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