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1o26

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{{STRUCTURE_1o26| PDB=1o26 | SCENE= }}
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'''Crystal structure of Thymidylate Synthase Complementing Protein (TM0449) from Thermotoga maritima with FAD and dUMP at 1.6 A resolution'''
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===Crystal structure of Thymidylate Synthase Complementing Protein (TM0449) from Thermotoga maritima with FAD and dUMP at 1.6 A resolution===
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==Overview==
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Like thymidylate synthase (TS) in eukaryotes, the thymidylate synthase-complementing proteins (TSCPs) are mandatory for cell survival of many prokaryotes in the absence of external sources of thymidylate. Details of the mechanism of this novel family of enzymes are unknown. Here, we report the structural and functional analysis of a TSCP from Thermotoga maritima and its complexes with substrate, analogs, and cofactor. The structures presented here provide a basis for rationalizing the TSCP catalysis and reveal the possibility of the design of an inhibitor. We have identified a new helix-loop-strand FAD binding motif characteristic of the enzymes in the TSCP family. The presence of a hydrophobic core with residues conserved among the TSCP family suggests a common overall fold.
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{{ABSTRACT_PUBMED_12791256}}
==About this Structure==
==About this Structure==
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[[Category: Thymidylate synthase complementing protein]]
[[Category: Thymidylate synthase complementing protein]]
[[Category: Tm0449]]
[[Category: Tm0449]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 03:15:40 2008''
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Revision as of 04:55, 29 July 2008

Image:1o26.png

Template:STRUCTURE 1o26

Crystal structure of Thymidylate Synthase Complementing Protein (TM0449) from Thermotoga maritima with FAD and dUMP at 1.6 A resolution

Template:ABSTRACT PUBMED 12791256

About this Structure

1O26 is a Single protein structure of sequence from Thermotoga maritima. Full crystallographic information is available from OCA.

Reference

Functional analysis of substrate and cofactor complex structures of a thymidylate synthase-complementing protein., Mathews II, Deacon AM, Canaves JM, McMullan D, Lesley SA, Agarwalla S, Kuhn P, Structure. 2003 Jun;11(6):677-90. PMID:12791256

Page seeded by OCA on Tue Jul 29 07:55:15 2008

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