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1o6u

From Proteopedia

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[[Image:1o6u.gif|left|200px]]
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{{Seed}}
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[[Image:1o6u.png|left|200px]]
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{{STRUCTURE_1o6u| PDB=1o6u | SCENE= }}
{{STRUCTURE_1o6u| PDB=1o6u | SCENE= }}
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'''THE CRYSTAL STRUCTURE OF HUMAN SUPERNATANT PROTEIN FACTOR'''
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===THE CRYSTAL STRUCTURE OF HUMAN SUPERNATANT PROTEIN FACTOR===
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==Overview==
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Supernatant protein factor (SPF) promotes the epoxidation of squalene catalyzed by microsomes. Several studies suggest its in vivo role in the cholesterol biosynthetic pathway by a yet unknown mechanism. SPF belongs to a family of lipid binding proteins called CRAL_TRIO, which include yeast phosphatidylinositol transfer protein Sec14 and tocopherol transfer protein TTP. The crystal structure of human SPF at a resolution of 1.9 A reveals a two domain topology. The N-terminal 275 residues form a Sec14-like domain, while the C-terminal 115 residues consist of an eight-stranded jelly-roll barrel similar to that found in many viral protein structures. The ligand binding cavity has a peculiar horseshoe-like shape. Contrary to the Sec14 crystal structure, the lipid-exchange loop is in a closed conformation, suggesting a mechanism for lipid exchange.
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The line below this paragraph, {{ABSTRACT_PUBMED_12429094}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 12429094 is the PubMed ID number.
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{{ABSTRACT_PUBMED_12429094}}
==About this Structure==
==About this Structure==
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[[Category: Lipid transfer]]
[[Category: Lipid transfer]]
[[Category: Transferase]]
[[Category: Transferase]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 03:27:17 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 23:28:16 2008''

Revision as of 20:28, 28 July 2008

Image:1o6u.png

Template:STRUCTURE 1o6u

THE CRYSTAL STRUCTURE OF HUMAN SUPERNATANT PROTEIN FACTOR

Template:ABSTRACT PUBMED 12429094

About this Structure

1O6U is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Crystal structure of the human supernatant protein factor., Stocker A, Tomizaki T, Schulze-Briese C, Baumann U, Structure. 2002 Nov;10(11):1533-40. PMID:12429094

Page seeded by OCA on Mon Jul 28 23:28:16 2008

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