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1o6y

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{{STRUCTURE_1o6y| PDB=1o6y | SCENE= }}
{{STRUCTURE_1o6y| PDB=1o6y | SCENE= }}
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'''CATALYTIC DOMAIN OF PKNB KINASE FROM MYCOBACTERIUM TUBERCULOSIS'''
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===CATALYTIC DOMAIN OF PKNB KINASE FROM MYCOBACTERIUM TUBERCULOSIS===
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==Overview==
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With the advent of the sequencing programs of prokaryotic genomes, many examples of the presence of serine/threonine protein kinases in these organisms have been identified. Moreover, these kinases could be classified as homologues of those belonging to the well characterized superfamily of the eukaryotic serine/threonine and tyrosine kinases. Eleven such kinases were recognized in the genome of Mycobacterium tuberculosis. Here we report the crystal structure of an active form of PknB, one of the four M. tuberculosis kinases that are conserved in the downsized genome of Mycobacterium leprae and are therefore presumed to play an important role in the processes that regulate the complex life cycle of mycobacteria. Our structure confirms again the extraordinary conservation of the protein kinase fold and constitutes a landmark that extends this conservation across the evolutionary distance between high eukaryotes and eubacteria. The structure of PknB, in complex with a nucleotide triphosphate analog, reveals an enzyme in the active state with an unprecedented arrangement of the Gly-rich loop associated with a new conformation of the nucleotide gamma-phosphoryl group. It presents as well a partially disordered activation loop, suggesting an induced fit mode of binding for the so far unknown substrates of this kinase or for some modulating factor(s).
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The line below this paragraph, {{ABSTRACT_PUBMED_12551895}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 12551895 is the PubMed ID number.
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{{ABSTRACT_PUBMED_12551895}}
==About this Structure==
==About this Structure==
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[[Category: Tbsgc]]
[[Category: Tbsgc]]
[[Category: Transferase,psi,protein structure initiative,tb structural genomics consortium,tb]]
[[Category: Transferase,psi,protein structure initiative,tb structural genomics consortium,tb]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 03:27:36 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Jul 27 17:43:48 2008''

Revision as of 14:43, 27 July 2008

Image:1o6y.png

Template:STRUCTURE 1o6y

CATALYTIC DOMAIN OF PKNB KINASE FROM MYCOBACTERIUM TUBERCULOSIS

Template:ABSTRACT PUBMED 12551895

About this Structure

1O6Y is a Single protein structure of sequence from Mycobacterium tuberculosis. Full crystallographic information is available from OCA.

Reference

Crystal structure of the catalytic domain of the PknB serine/threonine kinase from Mycobacterium tuberculosis., Ortiz-Lombardia M, Pompeo F, Boitel B, Alzari PM, J Biol Chem. 2003 Apr 11;278(15):13094-100. Epub 2003 Jan 27. PMID:12551895

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