1p8v
From Proteopedia
(New page: 200px<br /> <applet load="1p8v" size="450" color="white" frame="true" align="right" spinBox="true" caption="1p8v, resolution 2.60Å" /> '''CRYSTAL STRUCTURE O...) |
|||
| Line 1: | Line 1: | ||
| - | [[Image:1p8v. | + | [[Image:1p8v.jpg|left|200px]]<br /><applet load="1p8v" size="350" color="white" frame="true" align="right" spinBox="true" |
| - | <applet load="1p8v" size=" | + | |
caption="1p8v, resolution 2.60Å" /> | caption="1p8v, resolution 2.60Å" /> | ||
'''CRYSTAL STRUCTURE OF THE COMPLEX OF PLATELET RECEPTOR GPIB-ALPHA AND ALPHA-THROMBIN AT 2.6A'''<br /> | '''CRYSTAL STRUCTURE OF THE COMPLEX OF PLATELET RECEPTOR GPIB-ALPHA AND ALPHA-THROMBIN AT 2.6A'''<br /> | ||
| Line 11: | Line 10: | ||
==About this Structure== | ==About this Structure== | ||
| - | 1P8V is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with NAG, MES and DFP as [http://en.wikipedia.org/wiki/ligands ligands]. Active as [http://en.wikipedia.org/wiki/Thrombin Thrombin], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.21.5 3.4.21.5] Full crystallographic information is available from [http:// | + | 1P8V is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with <scene name='pdbligand=NAG:'>NAG</scene>, <scene name='pdbligand=MES:'>MES</scene> and <scene name='pdbligand=DFP:'>DFP</scene> as [http://en.wikipedia.org/wiki/ligands ligands]. Active as [http://en.wikipedia.org/wiki/Thrombin Thrombin], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.21.5 3.4.21.5] Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1P8V OCA]. |
==Reference== | ==Reference== | ||
| Line 29: | Line 28: | ||
[[Category: platelet glycoprotein receptor]] | [[Category: platelet glycoprotein receptor]] | ||
| - | ''Page seeded by [http:// | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri Feb 15 16:39:14 2008'' |
Revision as of 14:39, 15 February 2008
|
CRYSTAL STRUCTURE OF THE COMPLEX OF PLATELET RECEPTOR GPIB-ALPHA AND ALPHA-THROMBIN AT 2.6A
Contents |
Overview
Direct interaction between platelet receptor glycoprotein Ibalpha, (GpIbalpha) and thrombin is required for platelet aggregation and, activation at sites of vascular injury. Abnormal GpIbalpha-thrombin, binding is associated with many pathological conditions,including, occlusive arterial thrombosis and bleeding disorders. The crystal, structure of the GpIbalpha-thrombin complex at 2.6 angstrom resolution, reveals simultaneous interactions of GpIbalpha with exosite I of one, thrombin molecule,and with exosite II of a second thrombin molecule. In, the crystal lattice,the periodic arrangement of GpIbalpha-thrombin, complexes mirrors a scaffold that could serve as a driving force for tight, platelet adhesion. The details of these interactions reconcile, GpIbalpha-thrombin binding modes that are presently, controversial,highlighting two distinct interfaces that are potential, targets for development of novel antithrombotic drugs.
Disease
Known diseases associated with this structure: Bernard-Soulier syndrome, type A OMIM:[606672], Dysprothrombinemia OMIM:[176930], Hyperprothrombinemia OMIM:[176930], Hypoprothrombinemia OMIM:[176930], Nonarteritic anterior ischemic optic neuropathy, susceptibility to OMIM:[606672], von Willebrand disease, platelet-type OMIM:[606672]
About this Structure
1P8V is a Protein complex structure of sequences from Homo sapiens with , and as ligands. Active as Thrombin, with EC number 3.4.21.5 Full crystallographic information is available from OCA.
Reference
Crystal structure of the GpIbalpha-thrombin complex essential for platelet aggregation., Dumas JJ, Kumar R, Seehra J, Somers WS, Mosyak L, Science. 2003 Jul 11;301(5630):222-6. PMID:12855811
Page seeded by OCA on Fri Feb 15 16:39:14 2008
