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1o7v

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{{STRUCTURE_1o7v| PDB=1o7v | SCENE= }}
{{STRUCTURE_1o7v| PDB=1o7v | SCENE= }}
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'''HIGH RESOLUTION STRUCTURE OF SIGLEC-7'''
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===HIGH RESOLUTION STRUCTURE OF SIGLEC-7===
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==Overview==
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Sialic acid-binding immunoglobulin-like lectins (Siglecs) recognize sialylated glycoconjugates and play a role in cell-cell recognition. Siglec-7 is expressed on natural killer cells and displays unique ligand binding properties different from other members of the Siglec family. Here we describe the high resolution structures of the N-terminal V-set Ig-like domain of Siglec-7 in two crystal forms, at 1.75 and 1.9 A. The latter crystal form reveals the full structure of this domain and allows us to speculate on the differential ligand binding properties displayed by members of the Siglec family. A fully ordered N-linked glycan is observed, tethered by tight interactions with symmetry-related protein molecules in the crystal. Comparison of the structure with that of sialoadhesin and a model of Siglec-9 shows that the unique preference of Siglec-7 for alpha(2,8)-linked disialic acid is likely to reside in the C-C' loop, which is variable in the Siglec family. In the Siglec-7 structure, the ligand-binding pocket is occupied by a loop of a symmetry-related molecule, mimicking the interactions with sialic acid.
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(as it appears on PubMed at http://www.pubmed.gov), where 12438315 is the PubMed ID number.
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{{ABSTRACT_PUBMED_12438315}}
==About this Structure==
==About this Structure==
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[[Category: Sialic acid binding protein,lectin,cell adhesion,immune system]]
[[Category: Sialic acid binding protein,lectin,cell adhesion,immune system]]
[[Category: Siglec]]
[[Category: Siglec]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 03:29:51 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 04:01:22 2008''

Revision as of 01:01, 29 July 2008

Image:1o7v.png

Template:STRUCTURE 1o7v

HIGH RESOLUTION STRUCTURE OF SIGLEC-7

Template:ABSTRACT PUBMED 12438315

About this Structure

1O7V is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

High resolution crystal structures of Siglec-7. Insights into ligand specificity in the Siglec family., Alphey MS, Attrill H, Crocker PR, van Aalten DM, J Biol Chem. 2003 Jan 31;278(5):3372-7. Epub 2002 Nov 15. PMID:12438315

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