8uwp

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m (Protected "8uwp" [edit=sysop:move=sysop])
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'''Unreleased structure'''
 
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The entry 8uwp is ON HOLD
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==Crystal structure of SETDB1 Tudor domain in complex with MR43625==
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<StructureSection load='8uwp' size='340' side='right'caption='[[8uwp]], [[Resolution|resolution]] 1.77&Aring;' scene=''>
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Authors: Shrestha, S., Beldar, S., Dong, A., Ackloo, S., Brown, P.J., Arrowsmith, C.H., Edwards, A.M., Halabelian, L., Structural Genomics Consortium (SGC)
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== Structural highlights ==
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<table><tr><td colspan='2'>[[8uwp]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8UWP OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8UWP FirstGlance]. <br>
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Description: Crystal structure of SETDB1 Tudor domain in complex with MR43625
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.77&#8491;</td></tr>
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[[Category: Unreleased Structures]]
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=UNX:UNKNOWN+ATOM+OR+ION'>UNX</scene>, <scene name='pdbligand=XRU:(3S)-N-(4-chloro-3-{[2-(diethylamino)ethyl]carbamoyl}phenyl)-3-(diethylamino)pyrrolidine-1-carboxamide'>XRU</scene></td></tr>
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[[Category: Shrestha, S]]
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8uwp FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8uwp OCA], [https://pdbe.org/8uwp PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8uwp RCSB], [https://www.ebi.ac.uk/pdbsum/8uwp PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8uwp ProSAT]</span></td></tr>
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[[Category: Edwards, A.M]]
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</table>
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[[Category: Arrowsmith, C.H]]
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== Function ==
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[[Category: Dong, A]]
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[https://www.uniprot.org/uniprot/SETB1_HUMAN SETB1_HUMAN] Histone methyltransferase that specifically trimethylates 'Lys-9' of histone H3. H3 'Lys-9' trimethylation represents a specific tag for epigenetic transcriptional repression by recruiting HP1 (CBX1, CBX3 and/or CBX5) proteins to methylated histones. Mainly functions in euchromatin regions, thereby playing a central role in the silencing of euchromatic genes. H3 'Lys-9' trimethylation is coordinated with DNA methylation. Probably forms a complex with MBD1 and ATF7IP that represses transcription and couples DNA methylation and histone 'Lys-9' trimethylation. Its activity is dependent on MBD1 and is heritably maintained through DNA replication by being recruited by CAF-1. SETDB1 is targeted to histone H3 by TRIM28/TIF1B, a factor recruited by KRAB zinc-finger proteins.<ref>PMID:12869583</ref> <ref>PMID:14536086</ref> <ref>PMID:15327775</ref> <ref>PMID:17952062</ref>
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[[Category: Structural Genomics Consortium (Sgc)]]
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== References ==
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[[Category: Halabelian, L]]
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<references/>
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[[Category: Brown, P.J]]
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__TOC__
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[[Category: Beldar, S]]
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</StructureSection>
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[[Category: Ackloo, S]]
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[[Category: Homo sapiens]]
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[[Category: Large Structures]]
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[[Category: Ackloo S]]
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[[Category: Arrowsmith CH]]
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[[Category: Beldar S]]
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[[Category: Brown PJ]]
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[[Category: Dong A]]
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[[Category: Edwards AM]]
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[[Category: Halabelian L]]
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[[Category: Shrestha S]]

Revision as of 07:35, 22 November 2023

Crystal structure of SETDB1 Tudor domain in complex with MR43625

PDB ID 8uwp

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