From Proteopedia
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| | + | '''Unreleased structure''' |
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| - | ==Diphosphoinositol polyphosphate phosphohydrolase 1 (DIPP1/NUDT3) in complex with myo-5-PP-IP4, produced upon myo-(2OH)-IP5 phosphorylation by TvIPK==
| + | The entry 8tfa is ON HOLD until Paper Publication |
| - | <StructureSection load='8tfa' size='340' side='right'caption='[[8tfa]], [[Resolution|resolution]] 1.40Å' scene=''>
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| - | == Structural highlights ==
| + | Authors: Zong, G., Wang, H., Shears, S.B. |
| - | <table><tr><td colspan='2'>[[8tfa]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8TFA OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8TFA FirstGlance]. <br>
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| - | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.4Å</td></tr>
| + | Description: Diphosphoinositol polyphosphate phosphohydrolase 1 (DIPP1/NUDT3) in complex with 5-PP-IP4 (TvIPK''s product for 2-OH-IP5) |
| - | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=F:FLUORIDE+ION'>F</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=U6J:(1r,2R,3S,4r,5R,6S)-4-hydroxy-2,3,5,6-tetrakis(phosphonooxy)cyclohexyl+trihydrogen+diphosphate'>U6J</scene></td></tr>
| + | [[Category: Unreleased Structures]] |
| - | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8tfa FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8tfa OCA], [https://pdbe.org/8tfa PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8tfa RCSB], [https://www.ebi.ac.uk/pdbsum/8tfa PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8tfa ProSAT]</span></td></tr>
| + | [[Category: Shears, S.B]] |
| - | </table>
| + | [[Category: Wang, H]] |
| - | == Function ==
| + | [[Category: Zong, G]] |
| - | [https://www.uniprot.org/uniprot/NUDT3_HUMAN NUDT3_HUMAN] Cleaves a beta-phosphate from the diphosphate groups in PP-InsP5 (diphosphoinositol pentakisphosphate) and [PP]2-InsP4 (bisdiphosphoinositol tetrakisphosphate), suggesting that it may play a role in signal transduction. InsP6 (inositol hexakisphophate) is not a substrate. Acts as a negative regulator of the ERK1/2 pathway. Also able to catalyze the hydrolysis of dinucleoside oligophosphates, with Ap6A and Ap5A being the preferred substrates. The major reaction products are ADP and p4a from Ap6A and ADP and ATP from Ap5A. Also able to hydrolyze 5-phosphoribose 1-diphosphate.<ref>PMID:9822604</ref>
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| - | == References ==
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| - | <references/>
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| - | __TOC__
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| - | </StructureSection>
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| - | [[Category: Homo sapiens]] | + | |
| - | [[Category: Large Structures]]
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| - | [[Category: Shears SB]] | + | |
| - | [[Category: Wang H]] | + | |
| - | [[Category: Zong G]] | + | |
Revision as of 05:54, 22 November 2023
Unreleased structure
The entry 8tfa is ON HOLD until Paper Publication
Authors: Zong, G., Wang, H., Shears, S.B.
Description: Diphosphoinositol polyphosphate phosphohydrolase 1 (DIPP1/NUDT3) in complex with 5-PP-IP4 (TvIPKs product for 2-OH-IP5)
