1o9m

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[[Image:1o9m.gif|left|200px]]
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{{Seed}}
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[[Image:1o9m.png|left|200px]]
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{{STRUCTURE_1o9m| PDB=1o9m | SCENE= }}
{{STRUCTURE_1o9m| PDB=1o9m | SCENE= }}
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'''THE COMPLEX OF A NOVEL ANTIBIOTIC WITH THE AMINOACYL SITE OF THE BACTERIAL RIBOSOME REVEALED BY X-RAY CRYSTALLOGRAPHY.'''
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===THE COMPLEX OF A NOVEL ANTIBIOTIC WITH THE AMINOACYL SITE OF THE BACTERIAL RIBOSOME REVEALED BY X-RAY CRYSTALLOGRAPHY.===
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==Overview==
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The ribosome is an important target for aminoglycoside antibiotics; however, the clinical effectiveness of aminoglycosides has diminished due to bacterial resistance mechanisms. Here we report the X-ray structure of a novel synthetic aminoglycoside bound to the A site of the ribosome, its target for manifestation of activity. The structure validates the in silico design paradigms for the antibiotic and reveals the molecular interactions made by this novel antibiotic in prokaryotes.
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The line below this paragraph, {{ABSTRACT_PUBMED_12643685}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 12643685 is the PubMed ID number.
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{{ABSTRACT_PUBMED_12643685}}
==About this Structure==
==About this Structure==
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[[Category: A-site]]
[[Category: A-site]]
[[Category: Rna-antibiotic interaction]]
[[Category: Rna-antibiotic interaction]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 03:33:44 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 15:32:33 2008''

Revision as of 12:32, 29 July 2008

Image:1o9m.png

Template:STRUCTURE 1o9m

THE COMPLEX OF A NOVEL ANTIBIOTIC WITH THE AMINOACYL SITE OF THE BACTERIAL RIBOSOME REVEALED BY X-RAY CRYSTALLOGRAPHY.

Template:ABSTRACT PUBMED 12643685

About this Structure

1O9M is a Single protein structure. Full crystallographic information is available from OCA.

Reference

The complex of a designer antibiotic with a model aminoacyl site of the 30S ribosomal subunit revealed by X-ray crystallography., Russell RJ, Murray JB, Lentzen G, Haddad J, Mobashery S, J Am Chem Soc. 2003 Mar 26;125(12):3410-1. PMID:12643685

Page seeded by OCA on Tue Jul 29 15:32:33 2008

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