1oas

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Line 1: Line 1:
-
[[Image:1oas.gif|left|200px]]
+
{{Seed}}
 +
[[Image:1oas.png|left|200px]]
<!--
<!--
Line 9: Line 10:
{{STRUCTURE_1oas| PDB=1oas | SCENE= }}
{{STRUCTURE_1oas| PDB=1oas | SCENE= }}
-
'''O-ACETYLSERINE SULFHYDRYLASE FROM SALMONELLA TYPHIMURIUM'''
+
===O-ACETYLSERINE SULFHYDRYLASE FROM SALMONELLA TYPHIMURIUM===
-
==Overview==
+
<!--
-
The last step in cysteine biosynthesis in enteric bacteria is catalyzed by the pyridoxal 5'-phosphate-dependent enzyme O-acetylserine sulfhydrylase. Here we report the crystal structure at 2.2 A resolution of the A-isozyme of O-acetylserine sulfhydrylase isolated from Salmonella typhimurium. O-acetylserine sulfhydrylase shares the same fold with tryptophan synthase-beta from Salmonella typhimurium but the sequence identity level is below 20%. There are some major structural differences: the loops providing the interface to the alpha-subunit in tryptophan synthase-beta and two surface helices of tryptophan synthase-beta are missing in O-acetylserine sulfhydrylase. The hydrophobic channel for indole transport from the alpha to the beta active site of tryptophan synthase-beta is, not unexpectedly, also absent in O-acetylserine sulfhydrylase. The dimer interface, on the other hand, is more or less conserved in the two enzymes. The active site cleft of O-acetylserine sulfhydrylase is wider and therefore more exposed to the solvent. A possible binding site for the substrate O-acetylserine is discussed.
+
The line below this paragraph, {{ABSTRACT_PUBMED_9761678}}, adds the Publication Abstract to the page
 +
(as it appears on PubMed at http://www.pubmed.gov), where 9761678 is the PubMed ID number.
 +
-->
 +
{{ABSTRACT_PUBMED_9761678}}
==About this Structure==
==About this Structure==
Line 33: Line 37:
[[Category: Homodimer]]
[[Category: Homodimer]]
[[Category: Plp dependent enzyme]]
[[Category: Plp dependent enzyme]]
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 03:36:23 2008''
+
 
 +
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Jul 27 13:48:06 2008''

Revision as of 10:48, 27 July 2008

Image:1oas.png

Template:STRUCTURE 1oas

O-ACETYLSERINE SULFHYDRYLASE FROM SALMONELLA TYPHIMURIUM

Template:ABSTRACT PUBMED 9761678

About this Structure

1OAS is a Single protein structure of sequence from Salmonella typhimurium. Full crystallographic information is available from OCA.

Reference

Three-dimensional structure of O-acetylserine sulfhydrylase from Salmonella typhimurium., Burkhard P, Rao GS, Hohenester E, Schnackerz KD, Cook PF, Jansonius JN, J Mol Biol. 1998;283(1):121-33. PMID:9761678

Page seeded by OCA on Sun Jul 27 13:48:06 2008

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/1oas"
Personal tools